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Table 6 Linezolid Cmin of the first measurement (first Cmin) at 12, 24, 36, or 48 h after starting administration of fixed 600 mg every 12 h and ratio of first Cmin to mean Cmin under steady state in the RI group and non-RI group

From: Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients

Time after starting administration of fixed 600 mg every 12 h (h) Linezolid Cmin of first measurement (first Cmin), mean ± SD (range) Ratio of first Cmin to mean Cmin under steady state, median (IQR)
RI group n Non-RI group n P-value RI group n Non-RI group n P-value
12 8.9 ± 0.4 (8.6–9.4) 3 6.2 ± 3.7 (0.2–14.0) 17 0.090 52.0 (24.3–75.6) 3 52.0 (26.4–80.7) 17 0.96
24 12.3 ± 8.8 (2.9–24.3) 7 8.3 ± 3.6 (4.8–14.2) 5 0.75 81.8 (64.4–118.3) 7 58.2 (27.3–64.4) 5 0.051
36 18.8 ± 3.6 (16.2–21.3) 2 9.6 ± 7.8 (0.5–23.3) 7 0.19 67.6 (41.7–102.0) 2 61.3 (45.1–77.5) 7 0.88
48 25.3 ± 9.6 (15.8–36.1) 4 8.7 ± 4.8 (1.4–14.7) 8 0.0085 62.3 (45.8–79.1) 4 79.1 (55.0–86.8) 8 0.44
Total 15.7 ± 9.5 (2.9–36.1) 16 7.7 ± 4.9 (0.2–23.3) 37 0.0019 58.9 (37.8–89.1) 16 60.5 (38.7–79.9) 37 0.71
  1. Abbreviations: Cmin trough concentration, first Cmin Cmin of first measurement, RI renal impairment