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Table 4 Multivariate analysis of the association of phosphate levels and ICU mortality in selected subgroups of patients

From: Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock

  Hypophosphatemia group Hyperphosphatemia group  
Variable aOR (95% CI) P-value aOR (95% CI) P-value P-value for interaction
Age
 Age < 67 years 0.74 (0.36–1.50) 0.40 1.32 (0.80–2.20) 0.29 0.69
 Age > 67 years 0.35 (0.12–1.04) 0.06 1.84 (1.11–1.04) 0.02
Sex
 Male 0.56 (0.27–1.18) 0.13 1.79 (1.15–2.81) 0.01 0.65
 Female 0.65 (0.25–1.68) 0.38 1.35 (0.76–2.39) 0.31
Chronic respiratory disease
 Yes < 0.001 (< 0.001- > 999.9) 0.96 1.69 (0.37–7.8) 0.50 0.27
 No 0.63 (0.35–1.13) 0.12 1.58 (1.10–1.14) 0.01
Chronic cardiac disease
 Yes 0.54 (0.15–1.96) 0.35 2.23 (1.23–4.05) 0.008 0.48
 No 0.58 (0.30–1.12) 0.11 1.36 (0.87–2.11) 0.18
Chronic renal disease
 Yes < 0.001 (< 0.001- > 999.9) 0.96 1.82 (0.42–7.94) 0.43 0.97
 No 0.63 (0.35–1.14) 0.13 1.16 (1.11–2.30) 0.01
Chronic liver disease
 Yes 0.39 (0.05–3.15) 0.37 0.55 (0.13–2.25) 0.41 0.007
 No 0.62 (0.33–1.14) 0.12 1.68 (1.16–2.42) 0.006
Chronic immunosuppression
 Yes 0.72 (0.27–1.94) 0.52 1.93 (0.86–4.40) 0.52 0.19
 No 0.51 (0.24–1.07) 0.08 1.72 (1.15–2.56) 0.008
APACHE II score
  < 23 0.62 (0.27–1.43) 0.26 1.97 (1.07–3.62) 0.03 0.78
  > 23 0.57 (0.25–1.30) 0.18 1.51 (0.98–2.33) 0.06
Diabetes
 Yes 0.51 (0.17–1.53) 0.23 1.66 (0.96–2.88) 0.07 0.90
 No 0.60 (0.30–1.20) 0.15 1.36 (0.83–2.22) 0.22
Vasopressors
 Yes 0.58 (0.27–1.25) 0.16 1.45 (0.95–2.21) 0.09 0.89
 No 0.65 (0.26–1.62) 0.36 1.71 (0.89–3.29) 0.11
ICU duration (days)
  ≤ 5 0.71 (0.26–1.95) 0.50 1.35 (0.70–2.60) 0.37 0.59
  > 5 0.58 (0.27–1.23) 0.16 1.46 (0.92–2.30) 0.11
Estimated GFR
  ≤ 73 ml/min 0.61 (0.24–1.57) 0.30 1.72 (1.15–2.58) 0.009 0.18
  > 73 ml/min 0.60 (0.28–1.28) 0.18 1.04 (0.45–2.41) 0.93
Acute Kidney Injury
 Yes 0.39 (0.07–2.14) 0.28 1.49 (0.79–2.82) 0.22 0.53
 No 0.63 (0.34–1.17) 0.14 1.56 (1.02–2.40) 0.04
Type of admission
 Non-operative 0.55 (0.30–1.00) 0.05 1.6 (1.10–1.14) 0.01 0.89
 Post-operative 14 (0.45–434) 0.13 4.70 (0.22–97.50) 0.32
  1. aOR adjusted odds ratio, APACHE Acute Physiology and Chronic Health Evaluation, CI confidence interval, GFR glomerular filtration rate, ICU intensive care unit
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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