Fig. 3

Distribution of the concentration range of vancomycin. Vancomycin concentration–time profile from the Monte Carlo simulation with five typical cases. Deep and light pink colors represent the 5th and 95th percentiles of the simulated data, respectively. Red solid line represents the lower and upper boundaries of the therapeutic range of vancomycin. Horizontal axis: Time after achieving steady state (h); vertical axis: vancomycin concentration (mg/L). a. Neonates with 0.95 kg body weight (gestational age: 29 weeks, SCR: 100umol/L, 19 mg every 24 h); b. Neonates with 2.4 kg body weight (gestational age: 39 weeks, SCR: 70 μmol/L, 36 mg every 8 h: 0:00, 8:00, and 16:00); c. Neonates with 4 kg body weight (gestational age: 39 weeks, 28 days, SCR: 60 μmol/L, 60 mg every 8 h: 0:00,8:00, and 16:00); d. Infants with 5 kg body weight (gestational age: 39 weeks, 3 months, SCR: 32 μmol/L, 50 mg every 6 h: 0:00,6:00,12:00, and 18:00); e. Infants with 8 kg body weight (gestational age: 39 weeks, 9 months, SCR: 28 μmol/L, 80 mg every 6 h: 0:00, 6:00, 12:00, and 18:00)