Table 2 Parameter Value of the Final Model

CL

clearance

10.3

29.60%

4.322–16.278

V

distribution volume

50.6

7.50%

43.211–57.989

Θ1

weight coefficient on CL

1.06

9.40%

0.865–1.255

Θ2

Serum creatinine coefficient on CL

−0.315

20.70%

−0.443--0.187

Θ3

Co-therapy with ceftriaxone coefficient on CL

1.46

16.70%

0.982–1.938

η1

Between-subject variability of Clearance

0.145

27.70%

ε1

Proportional within-subject variability

0.194

16.10%