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Table 2 Parameter Value of the Final Model

From: Establishment of a population pharmacokinetics model of vancomycin in 94 infants with septicemia and its application in individualized therapy

Parameter Definition Estimates RSE (%) 95% confidence interval
CL clearance 10.3 29.60% 4.322–16.278
V distribution volume 50.6 7.50% 43.211–57.989
Θ1 weight coefficient on CL 1.06 9.40% 0.865–1.255
Θ2 Serum creatinine coefficient on CL −0.315 20.70% −0.443--0.187
Θ3 Co-therapy with ceftriaxone coefficient on CL 1.46 16.70% 0.982–1.938
η1 Between-subject variability of Clearance 0.145 27.70%  
ε1 Proportional within-subject variability 0.194 16.10%