Table 3 Model Selection Processa
| Model | Description & main characteristics | OFV value | △OFV value | Whether or not included |
|---|---|---|---|---|
| 1 | One compartment model | 1098.753 | 0 | YES |
| 2 | One compartment model, ETA was not estimated on V | 1102.375 | 3.622 | NO |
| Forward inclusion process | ||||
| 3 | Add WT on CL | 1000.624 | −69.045 | YES |
| 4 | Add SCR on CL | 988.23 | −12.394 | YES |
| 5 | Add co-therapy with ceftriaxone on CL | 978.401 | −9.829 | YES |
| Backward elimination process | ||||
| 6 | Remove WT on CL | 1016.409 | 44.627 | YES |
| 7 | Remove SCR on CL | 987.288 | 14.602 | YES |
| 8 | Remove co-therapy with ceftriaxone on CL | 981.069 | 8.187 | YES |