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Table 3 Model Selection Processa

From: Establishment of a population pharmacokinetics model of vancomycin in 94 infants with septicemia and its application in individualized therapy

Model Description & main characteristics OFV value OFV value Whether or not included
1 One compartment model 1098.753 0 YES
2 One compartment model, ETA was not estimated on V 1102.375 3.622 NO
Forward inclusion process
 3 Add WT on CL 1000.624 −69.045 YES
 4 Add SCR on CL 988.23 −12.394 YES
 5 Add co-therapy with ceftriaxone on CL 978.401 −9.829 YES
Backward elimination process
 6 Remove WT on CL 1016.409 44.627 YES
 7 Remove SCR on CL 987.288 14.602 YES
 8 Remove co-therapy with ceftriaxone on CL 981.069 8.187 YES
  1. aThis is a standard stepwise procedure for screening covariates in popPK analysis