Skip to main content

Table 5 The Combined Effect of HFD and NP Exposure on the Blood Biochemical Parameters in F1 and F2 male Rats

From: High-fat diet accelerate hepatic fatty acids synthesis in offspring male rats induced by perinatal exposure to nonylphenol

  

ND

HFD

P-value

Control-ND

NP-5-ND

Control-HFD

NP-5-HFD

Diet

Nonylphenol

D × N

ALT (U/L)

F1

85.05 ± 15.9

64.96 ± 12.93

97.17 ± 7.56

115.75 ± 7.05*#

> 0.05

> 0.05

< 0.05

F2

57.84 ± 6.10

72.57 ± 5.81*

59.98 ± 2.60

80.16 ± 5.52*#

> 0.05

< 0.05

< 0.05

AST (U/L)

F1

181 ± 13

212 ± 5*

201.94 ± 15.73

240 ± 23.53*#

> 0.05

< 0.05

< 0.05

F2

237 ± 16

235 ± 7

251.42 ± 21.97

296.34 ± 8.19*#

> 0.05

> 0.05

< 0.05

TG (mmol/L)

F1

0.68 ± 0.15

0.52 ± 0.09

1.23 ± 0.03

1.61 ± 0.04*#

> 0.05

> 0.05

< 0.05

F2

0.72 ± 0.21

0.78 ± 0.11

0.93 ± 0.20

1.70 ± 0.15*#

> 0.05

> 0.05

< 0.01

TC (mmol/L)

F1

1.97 ± 0.28

2.07 ± 0.08

2.15 ± 0.46

2.54 ± 0.29*#

> 0.05

> 0.05

< 0.05

F2

1.97 ± 0.21

3.38 ± 0.32*

2.09 ± 0.09

3.63 ± 0.08*#

> 0.05

< 0.05

< 0.01

HDL (mmol/L)

F1

2.06 ± 0.28

1.81 ± 0.09*

2.24 ± 0.37

2.18 ± 0.33

> 0.05

< 0.05

> 0.05

F2

1.88 ± 0.06

1.60 ± 0.13*

2.03 ± 0.12

1.75 ± 0.14

> 0.05

< 0.05

> 0.05

LDL (μg/mL)

F1

0.25 ± 0.06

0.30 ± 0.04*

0.29 ± 0.08

0.39 ± 0.04*#

> 0.05

< 0.05

< 0.05

F2

0.29 ± 0.01

0.57 ± 0.01

0.29 ± 0.05

0.68 ± 0.12*#

> 0.05

< 0.05

< 0.01

  1. Note: Means ± SE. n = 8 rats/group. *, P < 0.05 vs. Control-ND; **, P < 0.01 vs. Control-ND; #, Synergistic effect existed vs. Control-ND
Back to article page

BMC Pharmacology and Toxicology

ISSN: 2050-6511

Contact us