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Table 1 Effect of treatment with alamandine on water intake, urine output and renal toxicity markers in DOX-treated rats

From: Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats

 

Sham

Control

Ala

Dox

Dox + Ala

Water Intake (ml/kg/day)

63.10 ± 8.68

62.69 ± 6.90

70.31 ± 6.68

81.11 ± 9.84** ††

66.24 ± 10.21#

Urine output

(ml/kg/day)

27.29 ± 3.72

27.57 ± 3.55

34.03 ± 4.13###*†

14.39 ± 4.34***†††

31.20 ± 4.90###

Serum Creatinine (mg/dl)

0.71 ± 0.19

0.65 ± 0.16

0.67 ± 0.23

1. 61 ± 0.31***†††

1.06 ± 0.38##

Serum BUN

(mg/dl)

22.81 ± 4.99

22.98 ± 5.21

19.22 ± 6.33

43.45 ± 13.44***†††

28.32 ± 9.23#

Serum Albumin (g/dl)

4.06 ± 0.51

4.32 ± 0.58

3.96 ± 0.68

2.34 ± 0.78**††

3.20 ± 0.81

Urine Creatinine

(mg/dl)

76.12 ± 7.32

76.76 ± 6.98

81.24 ± 11.45

58.32 ± 13.82*†

68.98 ± 14.34

Urine Albumin

(mg/dl)

1.03 ± 0.21

0.7 ± 0.19

1.07 ± 0.24

2.89 ± 0.36***†††

2.05 ± 0.39###‎***†††‎

Creatinine Clearance (ml/min)

0.57 ± 0.14

0.64 ± 0.17

0.90 ± 0.53

0.08 ± 0.03**‎†‎

0.40 ± 0.18

  1. Data are expressed as mean ± SD; n = 7 for each group
  2. P < 0.05, ‎†‎‎†P < 0. 01, ‎†‎‎†‎‎†P < 0.001 compared to the sham‎;‎
  3. *P < 0.05, **P < 0. 01, ***P < 0.001 compared to the control;
  4. #P < 0.05, ##P < 0. 01, ###P < 0.001 compared to the DOX group