From: Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats
Sham | Control | Ala | Dox | Dox + Ala | |
---|---|---|---|---|---|
Water Intake (ml/kg/day) | 63.10 ± 8.68 | 62.69 ± 6.90 | 70.31 ± 6.68 | 81.11 ± 9.84** †† | 66.24 ± 10.21# |
Urine output (ml/kg/day) | 27.29 ± 3.72 | 27.57 ± 3.55 | 34.03 ± 4.13###*† | 14.39 ± 4.34***††† | 31.20 ± 4.90### |
Serum Creatinine (mg/dl) | 0.71 ± 0.19 | 0.65 ± 0.16 | 0.67 ± 0.23 | 1. 61 ± 0.31***††† | 1.06 ± 0.38## |
Serum BUN (mg/dl) | 22.81 ± 4.99 | 22.98 ± 5.21 | 19.22 ± 6.33 | 43.45 ± 13.44***††† | 28.32 ± 9.23# |
Serum Albumin (g/dl) | 4.06 ± 0.51 | 4.32 ± 0.58 | 3.96 ± 0.68 | 2.34 ± 0.78**†† | 3.20 ± 0.81 |
Urine Creatinine (mg/dl) | 76.12 ± 7.32 | 76.76 ± 6.98 | 81.24 ± 11.45 | 58.32 ± 13.82*† | 68.98 ± 14.34 |
Urine Albumin (mg/dl) | 1.03 ± 0.21 | 0.7 ± 0.19 | 1.07 ± 0.24 | 2.89 ± 0.36***††† | 2.05 ± 0.39###***††† |
Creatinine Clearance (ml/min) | 0.57 ± 0.14 | 0.64 ± 0.17 | 0.90 ± 0.53 | 0.08 ± 0.03**† | 0.40 ± 0.18 |