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Table 1 Effect of treatment with alamandine on water intake, urine output and renal toxicity markers in DOX-treated rats

From: Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats

  Sham Control Ala Dox Dox + Ala
Water Intake (ml/kg/day) 63.10 ± 8.68 62.69 ± 6.90 70.31 ± 6.68 81.11 ± 9.84** †† 66.24 ± 10.21#
Urine output
(ml/kg/day)
27.29 ± 3.72 27.57 ± 3.55 34.03 ± 4.13###*† 14.39 ± 4.34***††† 31.20 ± 4.90###
Serum Creatinine (mg/dl) 0.71 ± 0.19 0.65 ± 0.16 0.67 ± 0.23 1. 61 ± 0.31***††† 1.06 ± 0.38##
Serum BUN
(mg/dl)
22.81 ± 4.99 22.98 ± 5.21 19.22 ± 6.33 43.45 ± 13.44***††† 28.32 ± 9.23#
Serum Albumin (g/dl) 4.06 ± 0.51 4.32 ± 0.58 3.96 ± 0.68 2.34 ± 0.78**†† 3.20 ± 0.81
Urine Creatinine
(mg/dl)
76.12 ± 7.32 76.76 ± 6.98 81.24 ± 11.45 58.32 ± 13.82*† 68.98 ± 14.34
Urine Albumin
(mg/dl)
1.03 ± 0.21 0.7 ± 0.19 1.07 ± 0.24 2.89 ± 0.36***††† 2.05 ± 0.39###‎***†††‎
Creatinine Clearance (ml/min) 0.57 ± 0.14 0.64 ± 0.17 0.90 ± 0.53 0.08 ± 0.03**‎†‎ 0.40 ± 0.18
  1. Data are expressed as mean ± SD; n = 7 for each group
  2. P < 0.05, ‎†‎‎†P < 0. 01, ‎†‎‎†‎‎†P < 0.001 compared to the sham‎;‎
  3. *P < 0.05, **P < 0. 01, ***P < 0.001 compared to the control;
  4. #P < 0.05, ##P < 0. 01, ###P < 0.001 compared to the DOX group