Fig. 1

Summary Schematic of Study Design. Dosing of Cohort 2 commenced after at least 18 subjects in Cohort 1 had completed dosing and preliminary safety information had been reviewed. Two subjects were withdrawn; one for mild supraventricular tachycardia and one lost to follow-up. BID = twice daily; Met = metformin; RE = Remogliflozin etabonate