Table 2 Summary of Fasting Plasma Lactic Acid Concentration
| Lactic acid (mmol/L) |
Placebo + Metformin (N = 17) |
RE 500 mg + Metformin (N = 16)a |
RE 750 mg + Metformin (N = 17)b |
|---|---|---|---|
| A. Summary of Maximum On-Therapy Absolute concentrations and Changefrom Baseline; Mean (SD) | |||
| Absolute Values | 1.554 (0.5094) | 1.220 (0.2684) | 1.508 (0.4389) |
| Change From Baseline | 0.460 (0.2289) | 0.234 (0.3717) | 0.249 (0.5934) |
| B. Summary of Repeated measures analysis ofcovariance of change from baseline (vs. placebo) on selected days | |||
| Study Day 2 | |||
| Mean (SD) | 0.16 (0.266) | −0.07 (0.248) | −0.17 (0.419) |
| Difference (95% CI) | − 0.284 (− 0.485, − 0.083) | −0.246(− 0.445, − 0.047) | |
| p-value | 0.0066 | 0.0164 | |
| Study Day 6 | |||
| Mean (SD) | 0.08 (0.288) | −0.26 (0.310) | −0.26 (0.538) |
| Difference (95% CI) | −0.380 (− 0.603, − 0.157) | −0.254(− 0.472, − 0.036) | |
| p-value | 0.0013 | 0.0232 | |
| Study Day 13 | |||
| Mean (SD) | 0.00 (0.304) | −0.15 (0.485) | −0.33 (0.398) |
| Difference (95% CI) | −0.191 (− 0.414, 0.031) | −0.255 (− 0.475, − 0.034) | |
| p-value | 0.0905 | 0.0244 | |