Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin

Table 3 Summary of AmbulatoryBlood pressure monitoring

Time	Reading (Adjusted Mean Change from Baseline inmmHg; p-value)	RE 500 mg + Metformin(N = 14)	RE 750 mg + Metformin(N = 14)
24 h	Systolic	−2.8; p = 0.303	−4.0; p = 0.131
24 h	Diastolic	−2.0; p = 0.256	−3.3; p = 0.062
Daytime	Systolic	−3.4; p = 0.291	−2.4; p = 0.441
Daytime	Diastolic	−1.8; p = 0.461	−1.3; p = 0.586
Nighttime	Systolic	−8.4; p = 0.020	−7.1; p = 0.047
Nighttime	Diastolic	−6.5; p = 0.006	−4.8; p = 0.043

BP Blood pressure, RE Remogliflozin Etabonate
The changes were ANCOVA adjusted mean change from baseline to Day 13 vs. Placebo

ISSN: 2050-6511