Treatment | Day- 1 Metformin alone | Day 13 Metformin + RE | ||||
---|---|---|---|---|---|---|
AUC (0-tau) (hr.ng/mL) | Cmax (ng/mL) | tmax (hr) | AUC (0-tau) (hr.ng/mL) | Cmax (ng/mL) | tmax (hr) | |
Metformin + | 12,305 | 1967 | 2.0 | 13,955 | 2041 | 2.5 |
Placebo | (20) | (22) | (0.5–4.0) | (24) | (24) | (0.75–8.0) |
Metformin + | 13,895 | 2162 | 3.0 | 14,693 | 2166 | 2.5 |
RE 500 mg | (24) | (24) | (0.5–4.0) | (25) | (28) | (0.75–4.0) |
Metformin + | 11,319 | 1758 | 2.5 | 11,392 | 1695 | 2.0 |
RE 750 mg + | (33) | (26) | (0.5–4.0) | (37) | (34) | (0.5–4.1) |