Table 6 Summary of Pharmacokinetic Parameters of Remogliflozin Etabonate and its Metabolites

Analyte

AUC_(0-tau) or AUC _(0-last)^a

(hr.ng/ml)

C_max (ng/ml)

t_max

(hr)

AUC_(0-tau) or AUC _(0-last)^a

(hr.ng/ml)

C_max (ng/ml)

t_max

(hr)

RE

70.9

(45)

64.8

(55)

0.63

(0.25–3.0)

73.5

(47)

53.3

(94)

0.50

(0.25–4.0)

Remogliflozin

4894

(40)

1999

(60)

0.77

(0.50–6.0)

4928

(33)

1494

(39)

3.0

(0.5–4.0)

GSK279782

(active metabolite)

878

(44)

257

(51)

1.3

(0.75–6.0)

1053

(44)

251

(49)

4.0

(0.5–4.0)

Analyte

RE

121

(39)

137

(74)

0.50

(0.25–2.5)

121

(41)

101

(74)

0.48

(0.22–2.6)

Remogliflozin

8515

(31)

4008

(46)

0.75

(0.50–2.5)

6996

(39)

2508

(65)

1.3

(0.50–4.0)

GSK279782

(active metabolite)

1600

(50)

528

(43)

1.0

(0.75–3.0)

1298

(42)

326

(49)

3.0

(0.6–4.1)