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Table 7 Statistical Analysis of accumulation ratio basis PK Parameters of RemogliflozinEtabonate and Its Metabolites

From: Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin

PK Parameter

RE 500 mg + Metformin

RE 750 mg + Metformin

RE

Remogliflozin

GSK279782

RE

Remogliflozin

GSK279782

AUC(0-tau) or AUC(0-last)a

(hr.ng/ml)

0.99

(0.857–1.15)

1.00

(0.907–1.10)

1.17

(1.03–1.34)

1.02

(0.861–1.21)

0.82

(0.755–0.899)

0.84

(0.760–0.937)

  1. RE Remogliflozin Etabonate
  2. Values are point estimate (90% confidence interval) of the geometric least-square mean ratio, Day 13 versus Day 1.
  3. aAUC(0-tau) for remogliflozin and GSK279782; AUC(0-last) for RE