Skip to main content

Table 7 Statistical Analysis of accumulation ratio basis PK Parameters of RemogliflozinEtabonate and Its Metabolites

From: Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin

PK Parameter RE 500 mg + Metformin RE 750 mg + Metformin
RE Remogliflozin GSK279782 RE Remogliflozin GSK279782
AUC(0-tau) or AUC(0-last)a
(hr.ng/ml)
0.99
(0.857–1.15)
1.00
(0.907–1.10)
1.17
(1.03–1.34)
1.02
(0.861–1.21)
0.82
(0.755–0.899)
0.84
(0.760–0.937)
  1. RE Remogliflozin Etabonate
  2. Values are point estimate (90% confidence interval) of the geometric least-square mean ratio, Day 13 versus Day 1.
  3. aAUC(0-tau) for remogliflozin and GSK279782; AUC(0-last) for RE