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Table 4 Mixed Effects Model Regressions

From: Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence

Parameters

Model Parameters

Parameter

Estimate (C.I.)

P-Value

SD

AIC

BIC

logLik

 lme(TestCa ~ Race)

  Asian-Am.

− 0.2 (− 0.39, − 0.02)

0.0320

1.141

3566.977

3595.930

− 1777.489

  Hispanic-Am.

2.82 (2.65, 3)

2.5E-150

    

  NHCaucasian-Am.

4.17 (4, 4.34)

1.3E-246

    

 lme(TestCa ~ Ethnic_THC_Exposure)

  Ethnic_THC_Exp

0.05 (0.04, 0.06)

4.40E-31

0.202

− 1595.682

−1570.036

801.841

 lme(TestCa ~ Race + Ethnic_THC_Exposure)

  NHCaucasian-Am.

4.06 (3.88, 4.23)

1.13E-234

1.126

3546.406

3580.177

− 1766.203

  Hispanic-Am.

2.93 (2.76, 3.11)

4.23E-155

    

  Ethnic_THC_Exp

0.24 (0.15, 0.32)

2.13E-07

    

 lme(TestCa ~ Race * Ethnic_THC_Exposure)

  NHCaucasian-Am.

4.12 (3.95, 4.3)

9.4E-236

1.115

3539.109

3587.320

− 1759.554

  Hispanic-Am.

3.17 (2.96, 3.37)

1.5E-141

    

  Hispanic-Am.: Ethnic_THC_Exp

0.58 (0.4, 0.77)

6.6E-10

    

  NHCaucasian-Am.: Ethnic_THC_Exp

0.16 (0.05, 0.27)

0.0044

    

  Asian-Am.: Ethnic_THC_Exp

0.15 (−0.12, 0.43)

0.2753

    

  Asian-Am.

0.06 (− 0.42, 0.54)

0.8075

    

  NHAfrican-Am.: Ethnic_THC_Exp

−0.05 (− 0.35, 0.25)

0.7381

    

 lme(TestCa ~ Year * Race)

  Year: Hispanic-Am.

0.2 (0.17, 0.22)

2.9E-38

1.036

3427.797

3476.008

− 1703.898

  Year: NHCaucasian-Am.

0.02 (0.01, 0.04)

0.0032

    

  Hispanic-Am.

−396.69 (− 504.97, −288.41)

1.5E-12

    

 lme(TestCa ~ Year * Ethnic_THC_Exposure)

  Ethnic_THC_Exp

1.39 (1.25, 1.53)

1.51E-72

2.110

4659.713

4683.846

− 2324.857

  Year

−0.14 (−0.18, − 0.11)

2.21E-17

    

Additive Model

 lme(Rate ~ Cigarettes + AUD + Ethnic_THC_Exp + Analgesics + Cocaine)

  AUD

5.49 (5.11, 5.87)

6.57E-162

0.180

− 2610.768

− 2559.484

1313.384

  Ethnic_THC_Exp

0.05 (0.04, 0.06)

5.80E-31

    

  Cocaine

−2.46 (−3.3, −1.62)

1.17E-08

    

  Analgesics

−0.13 (− 0.16, − 0.1)

3.09E-21

    

  Cigarettes

− 1.12 (− 1.27, − 0.97)

7.42E-49

    

Interactive Model - 3-Way

 lme(Rate ~ Cigarettes * AUD * Ethnic_THC_Exp + Analgesics + Cocaine)

  Cigarettes: AUD

23.11 (21.54, 24.67)

2.14E-169

0.179

− 2675.013

− 2617.321

1346.507

  Cigarettes: Ethnic_THC_Exp

0.44 (0.31, 0.57)

5.22E-11

    

  Ethnic_THC_Exp

−0.05 (− 0.08, − 0.01)

3.80E-03

    

  Cocaine

−1.96 (−2.8, − 1.11)

6.09E-06

    

  Analgesics

− 0.13 (− 0.16, − 0.11)

2.56E-22

    

  Cigarettes

− 2.4 (− 2.59, − 2.2)

2.39E-124

    

Interactive Model - 4-Way

 lme(Rate ~ Cigarettes * AUD * Ethnic_THC_Exp * Analgesics + Cocaine)

  Cigarettes: AUD

23.48 (21.9, 25.05)

6.73E-172

0.177

− 2725.041

− 2648.125

1374.520

  Analgesics

0.31 (0.15, 0.48)

0.0002

    

  Ethnic_THC_Exp: Analgesics

0.22 (0.07, 0.37)

0.0036

    

  Ethnic_THC_Exp

0.64 (0.17, 1.1)

0.0072

    

  Cigarettes: Ethnic_THC_Exp

−3.8 (−5.8, −1.79)

0.0002

    

  Cigarettes: Ethnic_THC_Exp: Analgesics

−1.38 (−2.03, −0.73)

3.19E-05

    

  Cocaine

−1.87 (−2.71, − 1.02)

1.62E-05

    

  Cigarettes: Analgesics

−2.21 (− 2.96, − 1.47)

6.05E-09

    

  Cigarettes

−9.3 (− 11.61, −6.99)

3.98E-15

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