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Table 5 Mixed Effects Model Regressions

From: Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence

Parameters

Model Parameters

Instrumental Variable

Parameter

Estimate (C.I.)

P-Value

S.D.

R-Squared

Wald ChiSqu.

dF

P

 

ivreg(TestCa ~ Race)

       
 

Race_Asian

0.26 (−25.24, 25.77)

0.984

132.073

0.8888

2463

3921

< 2.2E-16

 

Race_Hispanic

2.7 (−13.73, 19.12)

0.748

     
 

Race_NHWhite

3.5 (−12.93, 19.92)

0.677

     
 

ivreg(TestCa ~ Ethnic_THC_Exposure)

      
 

Ethnic_THC_Exp

0.89 (0.88, 0.91)

<< 2.3E-320

102.3782

0.9332

1.29E+ 04

1923

<< 2.3E-320

 

ivreg(Rate ~ Ethn_THC_Exposure + Race)

       
 

Ethn_THC_Exposure: NHCaucasian-Am._THC_Exposure

0.08 (0.02, 0.13)

0.0095

8.4472

0.0361

29.06

64,493

<< 1.0E-320

 

Ethn_THC_Exposure: NHAfrican-Am._THC_Exposure

−0.09 (−0.14, −0.03)

0.0032

     
 

Ethn_THC_Exposure: NHPI_THC_Exposure

−0.19 (− 0.25, − 0.13)

3.4E-09

     
 

Ethn_THC_Exposure: Hispanic-Am._THC_Exposure

−0.25 (− 0.32, − 0.18)

4.2E-13

     
 

Ethn_THC_Exposure: Asian-Am._THC_Exposure

− 0.63 (− 0.74, − 0.52)

3.6E-29

     
 

Ethnic_THC_Exp

− 0.35 (− 0.4, − 0.3)

1.5E-38

     
 

ivreg(TestCaRt ~ log(EthnTHCExp) * Race)

      
 

NHWhite: Ethn_THC_Exp

1.22 (1.16, 1.27)

6.9E−128

95.9894

0.9430

3703

4920

< 2e-16

 

Hispanic: Ethn_THC_Exp

1.48 (1.38, 1.59)

5.6E-214

     
 

ivreg(TestCaRt ~ log(EthnTHCExp) * Race)

THC

RaceAsian

3.88E+ 05 (−8.93E+ 07, 9.01E+ 07)

0.993

130,195

-1.1E-05

9.013E+ 05

3921

1.0000

Cannabigerol

RaceHispanic

1.47E+ 05 (−3.38E+ 07, 3.40E+ 07)

0.993

     

Cannabinol

RaceNHWhite

1.47E+ 05 (− 3.38E+ 07, 3.41E+ 07)

0.993

     
 

ivreg(TestCa ~ Cigarettes * AUD * Ethn_THC_Exposure + Race + Cocaine + MHY + Analgesics)

 

AUD

138.37 (126.96, 149.78)

< 2e-16

24.2846

0.9962

2.04E+ 04

12,912

< 2.2E-16

 

AUD: Ethnic_THC_Exp

312.53 (290.54, 334.53)

< 2e-16

     
 

Cigarettes: Ethnic_THC_Exp

150.41 (139.67, 161.15)

< 2e-16

     
 

Analgesics

1.07 (0.67, 1.47)

1.8E-07

     
 

NHCaucasian-Am.

3.25 (0.22, 6.28)

0.0361

     
 

Hispanic-Am.

2.91 (−0.12, 5.93)

0.0597

     
 

Cocaine

− 132.56 (−150.11, −115.01)

< 2e-16

     
 

Cigarettes

−45.52 (−50.67, −40.37)

< 2e-16

     
 

Ethnic_THC_Exp

−22.08 (−24, −20.17)

< 2e-16

     
 

MHY

−12.03 (− 12.98, − 11.08)

< 2e-16

     
 

Cigarettes: AUD: Ethnic_THC_Exp

− 2032.86 (− 2169.16, − 1896.55)

< 2e-16

     
 

ivreg(TestCa ~ Cigarettes * AUD * Ethnic_THC_Exp * Race + Cocaine + MHY + Analgesics)

THC

Cigarettes

30.94 (21.36, 40.52)

3.9E-10

16.2755

0.0138

20.04

3921

1.37E-12

Cannabigerol

Ethnic_THC_Exp

0.55 (0.05, 1.05)

0.0298

     

Cannabinol

AUD

−49.84 (−64.89, −34.78)

1.4E-10

     
 

ivreg(Rate ~ Cigarettes * AUD + Analgesics + Cocaine + MHY + Race * Ethnic_THC_Exposure)

 

Cocaine

61.73 (56.9, 66.56)

6.1E-130

6.8060

0.3801

173.4

16,4483

<< 1.0E-320

 

Cigarettes: AUD

142.1 (126.47, 157.73)

5.2E-69

     
 

NHPI

0.52 (0.34, 0.7)

1.8E-08

     
 

Ethnic_THC_Exp

0.32 (0.2, 0.43)

4.7E-08

     
 

Asian-Am.

0.44 (0.25, 0.63)

6.8E-06

     
 

Hispanic-Am.

0.24 (0.06, 0.42)

0.00752

     
 

Asian-Am.: Ethnic_THC_Exp

−0.41 (−0.56, −0.26)

1.68E-07

     
 

NHPI: Ethnic_THC_Exp

−0.37 (− 0.5, − 0.24)

2.96E-08

     
 

Analgesics

−1.13 (−1.29, − 0.97)

7.65E-44

     
 

Cigarettes

−38.49 (−42.35, −34.63)

3.90E-82

     
 

MHY

−9.58 (−10.06, −9.1)

4.1E-289

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