Table 3 Coagulation parameters of Sprague Dawley rats administration with subtilisin QK for 28 days and 28 days recovery

D₂₈

PT

16.40 ± 0.63

16.42 ± 0.46

16.72 ± 0.56

16.81 ± 0.47

15.36 ± 0.40

16.25 ± 0.92*

15.85 ± 0.71

15.98 ± 0.50

APTT

23.74 ± 2.82

21.97 ± 2.67

19.81 ± 1.65*

19.96 ± 2.22*

20.12 ± 2.31

19.08 ± 1.98

20.17 ± 1.87

17.79 ± 2.18

TT

32.47 ± 1.48

32.39 ± 2.18

32.44 ± 1.83

32.38 ± 1.01

32.46 ± 2.29

33.13 ± 1.82

34.03 ± 1.05

31.74 ± 1.27

FIB

3.01 ± 0.21

2.93 ± 0.22

3.10 ± 0.49

3.18 ± 0.32

2.50 ± 0.24

2.64 ± 0.33

2.61 ± 0.18

2.48 ± 0.26

D₅₆

PT

16.64 ± 0.50

17.14 ± 1.02

17.52 ± 1.13

16.88 ± 0.91

17.10 ± 0.66

16.62 ± 0.41

16.10 ± 0.39*

16.02 ± 0.54*

APTT

23.72 ± 2.30

23.26 ± 0.57

25.78 ± 4.29

23.26 ± 1.79

19.78 ± 1.08

18.98 ± 1.14

20.36 ± 2.22

20.86 ± 1.80

TT

36.68 ± 0.96

35.28 ± 1.84

35.78 ± 2.02

35.66 ± 1.14

36.94 ± 1.27

35.38 ± 1.03

34.98 ± 1.58

36.68 ± 1.53

FIB

2.69 ± 0.15

2.87 ± 0.24

2.95 ± 0.19

2.91 ± 0.26

2.23 ± 0.32

2.28 ± 0.18

2.43 ± 0.09

2.21 ± 0.06