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Table 4 Absolute organ weights of Sprague Dawley rats administration with subtilisin QK for 28 days and 28 days recovery

From: Safety assessment of subtilisin QK in rats

  

Male

Female

  

Control

2500 FU/kg

7500 FU/kg

25,000 FU/kg

Control

2500 FU/kg

7500 FU/kg

25,000 FU/kg

D28

heart

1.361 ± 0.157

1.284 ± 0.100

1.353 ± 0.161

1.290 ± 0.103

0.899 ± 0.109

0.877 ± 0.129

0.979 ± 0.264

0.875 ± 0.076

n = 10

liver

10.591 ± 1.201

10.509 ± 1.030

10.769 ± 1.015

10.920 ± 1.114

6.804 ± 0.701

6.636 ± 0.708

6.520 ± 0.987

6.510 ± 0.541

 

spleen

0.712 ± 0.160

0.725 ± 0.134

0.714 ± 0.085

0.732 ± 0.128

0.500 ± 0.069

0.483 ± 0.044

0.514 ± 0.051

0.473 ± 0.038

 

kidenys

2.789 ± 0.198

2.600 ± 0.237

2.768 ± 0.163

2.695 ± 0.208

1.747 ± 0.204

1.743 ± 0.154

1.692 ± 0.221

1.709 ± 0.170

 

thymus

0.486 ± 0.113

0.469 ± 0.073

0.497 ± 0.123

0.428 ± 0.077

0.385 ± 0.108

0.353 ± 0.070

0.337 ± 0.091

0.375 ± 0.073

 

adrenals

0.072 ± 0.008

0.072 ± 0.013

0.073 ± 0.007

0.075 ± 0.013

0.086 ± 0.010

0.083 ± 0.015

0.077 ± 0.016

0.080 ± 0.016

 

testis

3.041 ± 0.368

2.903 ± 0.242

2.986 ± 0.108

3.003 ± 0.261

 

epididymis

0.902 ± 0.097

0.887 ± 0.078

0.920 ± 0.074

0.894 ± 0.074

 

uterus

0.518 ± 0.074

0.527 ± 0.169

0.491 ± 0.061

0.621 ± 0.184

 

ovaries

0.090 ± 0.014

0.094 ± 0.032

0.092 ± 0.011

0.096 ± 0.021

 

brain

1.967 ± 0.097

1.986 ± 0.062

1.958 ± 0.077

1.984 ± 0.081

1.909 ± 0.080

1.889 ± 0.072

1.905 ± 0.098

1.863 ± 0.081

D56

heart

1.605 ± 0.203

1.535 ± 0.074

1.661 ± 0.244

1.486 ± 0.016

0.915 ± 0.059

0.984 ± 0.102

1.065 ± 0.134

0.959 ± 0.058

n = 5

liver

13.193 ± 1.495

12.676 ± 0.890

13.032 ± 1.653

12.452 ± 1.449

7.476 ± 1.002

7.664 ± 0.660

7.630 ± 1.037

7.374 ± 0.486

 

spleen

0.793 ± 0.087

0.732 ± 0.091

0.814 ± 0.059

0.798 ± 0.104

0.535 ± 0.047

0.558 ± 0.048

0.518 ± 0.074

0.557 ± 0.112

 

kidenys

3.447 ± 0.331

3.327 ± 0.208

3.207 ± 0.466

3.409 ± 0.444

1.754 ± 0.079

1.925 ± 0.202

1.931 ± 0.240

1.883 ± 0.164

 

thymus

0.326 ± 0.071

0.341 ± 0.114

0.402 ± 0.067

0.402 ± 0.026

0.259 ± 0.051

0.297 ± 0.075

0.318 ± 0.045

0.252 ± 0.070

 

adrenals

0.074 ± 0.011

0.076 ± 0.012

0.067 ± 0.009

0.075 ± 0.018

0.081 ± 0.010

0.077 ± 0.008

0.084 ± 0.012

0.080 ± 0.009

 

testis

3.329 ± 0.132

3.281 ± 0.158

3.553 ± 0.501

3.271 ± 0.152

 

epididymis

1.426 ± 0.108

1.232 ± 0.041*

1.391 ± 0.142

1.403 ± 0.070

 

uterus

0.590 ± 0.174

0.510 ± 0.047

0.631 ± 0.034

0.653 ± 0.187

 

ovaries

0.091 ± 0.012

0.094 ± 0.015

0.086 ± 0.023

0.077 ± 0.012

 

brain

2.139 ± 0.092

2.140 ± 0.076

2.153 ± 0.095

2.148 ± 0.045

1.948 ± 0.037

1.964 ± 0.052

1.936 ± 0.129

1.918 ± 0.072

  1. *p < 0.05