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Table 5 Relative mean organ weights of Sprague Dawley rats administration with subtilisin QK for 28 days and 28 days recovery

From: Safety assessment of subtilisin QK in rats

  

Male

Female

  

Control

2500 FU/kg

7500 FU/kg

25,000 FU/kg

Control

2500 FU/kg

7500 FU/kg

25,000 FU/kg

D28

heart

0.354 ± 0.024

0.338 ± 0.019

0.351 ± 0.031

0.340 ± 0.021

0.368 ± 0.029

0.359 ± 0.032

0.406 ± 0.109

0.376 ± 0.036

n = 10

liver

2.753 ± 0.180

2.759 ± 0.167

2.798 ± 0.151

2.875 ± 0.199

2.787 ± 0.137

2.721 ± 0.185

2.691 ± 0.230

2.786 ± 0.157

 

spleen

0.185 ± 0.037

0.190 ± 0.030

0.186 ± 0.021

0.192 ± 0.026

0.205 ± 0.020

0.198 ± 0.014

0.214 ± 0.024

0.203 ± 0.023

 

kidenys

0.727 ± 0.033

0.683 ± 0.044

0.721 ± 0.046

0.710 ± 0.034

0.715 ± 0.042

0.716 ± 0.047

0.699 ± 0.048

0.731 ± 0.052

 

thymus

0.127 ± 0.028

0.123 ± 0.018

0.129 ± 0.029

0.112 ± 0.018

0.156 ± 0.033

0.145 ± 0.028

0.139 ± 0.032

0.160 ± 0.029

 

adrenals

0.019 ± 0.003

0.019 ± 0.004

0.019 ± 0.003

0.020 ± 0.003

0.035 ± 0.004

0.034 ± 0.005

0.032 ± 0.006

0.034 ± 0.005

 

testis

0.792 ± 0.080

0.765 ± 0.070

0.778 ± 0.043

0.792 ± 0.059

 

epididymis

0.235 ± 0.022

0.233 ± 0.020

0.240 ± 0.026

0.237 ± 0.025

 

uterus

0.214 ± 0.036

0.215 ± 0.060

0.205 ± 0.029

0.268 ± 0.087

 

ovaries

0.037 ± 0.006

0.039 ± 0.014

0.038 ± 0.006

0.041 ± 0.008

 

brain

0.513 ± 0.018

0.524 ± 0.037

0.510 ± 0.031

0.524 ± 0.039

0.787 ± 0.060

0.777 ± 0.042

0.793 ± 0.063

0.800 ± 0.061

D56

heart

0.337 ± 0.020

0.319 ± 0.023

0.330 ± 0.021

0.302 ± 0.020

0.345 ± 0.027

0.344 ± 0.040

0.378 ± 0.027

0.338 ± 0.016

n = 5

liver

2.771 ± 0.151

2.633 ± 0.198

2.596 ± 0.202

2.515 ± 0.171

2.820 ± 0.450

2.675 ± 0.190

2.711 ± 0.226

2.600 ± 0.135

 

spleen

0.168 ± 0.026

0.152 ± 0.018

0.163 ± 0.022

0.161 ± 0.019

0.202 ± 0.021

0.195 ± 0.012

0.184 ± 0.014

0.197 ± 0.039

 

kidenys

0.725 ± 0.036

0.690 ± 0.036

0.637 ± 0.049

0.689 ± 0.068

0.661 ± 0.044

0.670 ± 0.041

0.687 ± 0.068

0.663 ± 0.033

 

thymus

0.069 ± 0.013

0.071 ± 0.024

0.081 ± 0.017

0.082 ± 0.009

0.098 ± 0.020

0.103 ± 0.025

0.114 ± 0.015

0.088 ± 0.022

 

adrenals

0.016 ± 0.003

0.016 ± 0.002

0.014 ± 0.002

0.015 ± 0.003

0.030 ± 0.003

0.027 ± 0.002

0.030 ± 0.007

0.028 ± 0.003

 

testis

0.703 ± 0.057

0.682 ± 0.045

0.708 ± 0.066

0.664 ± 0.055

 

epididymis

0.301 ± 0.034

0.256 ± 0.013*

0.277 ± 0.008

0.284 ± 0.017

 

uterus

0.223 ± 0.068

0.178 ± 0.014

0.226 ± 0.019

0.230 ± 0.067

 

ovaries

0.034 ± 0.005

0.033 ± 0.005

0.031 ± 0.007

0.027 ± 0.005

 

brain

0.453 ± 0.047

0.444 ± 0.007

0.431 ± 0.026

0.436 ± 0.032

0.734 ± 0.036

0.687 ± 0.039

0.692 ± 0.059

0.678 ± 0.037

  1. *p < 0.05