Table 6 Main histopathology findings of Sprague Dawley rats administration with subtilisin QK for 28-day and 28-day recovery
Male | Female | |||||||
|---|---|---|---|---|---|---|---|---|
Control | 25,000 FU/kg | Control | 25,000 FU/kg | |||||
D28 | D56 | D28 | D56 | D28 | D56 | D28 | D56 | |
Lung, Pulmonary hemorrhage, limitations | 3/10 | 0/5 | 1/10 | 0/5 | 1/10 | 0/5 | 1/10 | 0/5 |
Pancreas, Leaflet atrophy, limitations (slight) | 0/10 | 0/5 | 1/10 | 0/5 | 0/10 | 0/5 | 0/10 | 0/5 |
Sialaden, Granular tube eosinophilic particle reduction (slight) | 0/10 | 0/5 | 1/10 | 0/5 | 0/10 | 0/5 | 0/10 | 0/5 |
Ileum, Pei’s mineralization stove (slight) | 0/10 | 0/5 | 2/10 | 0/5 | 0/10 | 0/5 | 0/10 | 0/5 |
Liver, Inflammatory cell infiltration, focal (slight) | 1/10 | 0/5 | 1/10 | 1/5 | 0/10 | 1/5 | 0/10 | 0/5 |
Liver, Hepatic steatosis, lobular periphery | 0/10 | 0/5 | 0/10 | 0/5 | 1/10 | 0/5 | 2/10 | 0/5 |
Kidney, Tubular basophilic lesion, focal (slight) | 3/10 | 2/5 | 2/10 | 1/5 | 1/10 | 0/5 | 1/10 | 1/5 |
Bladder, mesenteric mineralization (slight) | 0/10 | 0/5 | 1/10 | 0/5 | 0/10 | 0/5 | 0/10 | 0/5 |
Testicular, submucosal and interstitial hemorrhage, one side | 0/10 | 0/5 | 1/10 | 0/5 | – | – | – | – |
Prostatic, interstitial lymphocytic infiltration | 0/10 | 1/5 | 1/10 | 2/5 | – | – | – | – |
Eye, Retinal dysplasia (slight) | 1/10 | 0/5 | 1/10 | 0/5 | 0/10 | 0/5 | 2/10 | 0/5 |
Harrington gland, Lymphocyte infiltration, one side (slight) | 1/10 | 0/5 | 0/10 | 0/5 | 0/10 | 0/5 | 0/10 | 0/5 |