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Table 3 Complete blood count in male rats that received melittin post isoniazid and rifampicin-induced hepatotoxicity

From: Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats

 

NC

T

Mel 15

Mel 30

NR

WBCs(Ă—103/ÎĽl)

8.75 ± 1.19

5.45 ± 2.09

11.91 ± 1.32b****

14.13 ± 2.78b****

9.525 ± 2.00b*

LYM (%)

70.12 ± 7.82

79.23 ± 7.44

75.77 ± 4.19

70.52 ± 9.36

67.67 ± 11.65

MON (%)

4.55 ± 2.20

4.433 ± 2.12

7.117 ± 2.38

5.1 ± 2.18

5.75 ± 1.86

NEU (%)

19.5 ± 4.33

5.633 ± 1.09a**

13.73 ± 2.24

21.17 ± 8.98b**

22.85 ± 9.88b***

EOS (%)

1.15 ± 0.23

1.22 ± 0.26

3.23 ± 1.55b*

3.48 ± 1.43b*

3.65 ± 1.36b**

BAS (%)

0.08 ± 0.04

9.483 ± 4.41a****

0.15 ± 0.05b****

0.1 ± 0.0b****

0.08 ± 0.04b****

RBCs) × 106/μl)

9.033 ± 0.852

7.755 ± 0.26 a**

7.90 ± 0.22

7.952 ± 0.69

7.305 ± 0.34

Hb (g/dl)

15.18 ± 0.80

13.03 ± 0.89a**

14.88 ± 0.32b**

15.17 ± 0.74b**

14.5 ± 1.17b*

Hct (%)

48.78 ± 2.67

40.67 ± 2.28a***

48.22 ± 1.90b**

49.17 ± 2.47b***

47.6 ± 4.46b**

MCV (Ć’L)

65.3 ± 3.31

52.4 ± 1.69a****

61.03 ± 2.11b**

62.12 ± 3.81b***

65.23 ± 5.48b****

MCH (pg)

20.32 ± 0.79

17.52 ± 0.65a***

18.85 ± 0.35

19.12 ± 1.15b*

19.85 ± 1.27b**

MCHC (g/dL)

31.13 ± 0.41

33.37 ± 0.38a****

30.90 ± 0.99b****

30.83 ± 0.36b****

30.5 ± 0.97b****

PLT (Ă—103/ÎĽl)

777 ± 68.9

427.5 ± 146.5a**

827.8 ± 76.3b***

794.5 ± 130.6b**

607.7 ± 246.4

RDW-CV (%)

18.22 ± 2.1

24.35 ± 2.1a****

27.1 ± 1.84

28.65 ± 1.93b**

24.75 ± 1.56

  1. Results are expressed as mean ± SD (n = 6)
  2. WBCs White Blood Cells; Lym lymphocytes; Mon: Monocytes; Neu Neutrophils; EOS Eosinophils; Bas Basophils; RBCs Red Blood Cells; Hb Hemoglobin; Hct Hematocrit; MCV Mean corpuscular volume; MCH Mean Corpuscular Hemoglobin; MCHC Mean corpuscular Hemoglobin concentration; PLT platelets; RDW-CV Red blood cell distribution width - Coefficient of Variation
  3. NC control, T Toxic, Mel15 Melittin15ÎĽg, Mel 30 Melittin30ÎĽg, NR Normal recovery
  4. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. a: significant Vs NC group, b: significant Vs T group