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Table 4 In situ evaluation of liver from rats that received melittin post isoniazid and rifampicin-induced hepatotoxicity

From: Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats

  NC T Mel15 Mel30 NR
Amyloids ++++ +
  1.33 ± 0.52 17.5 ± 6.47a**** 2.67 ± 1.21 b**** 1.5 ± 0.55b**** 3.83 ± 1.72 b****
Congestion + ++++ + + +++
  1.33 ± 0.52 6.67 ± 1.36 a**** 2.4 ± 1b*** 2.17 ± 0.98b*** 5.17 ± 2.56
Ballooned hepatocytes ++++ + ++ ++
4 ± 2 86 ± 39.43a**** 30 ± 11.65b** 49.4 ± 17.81 54.3 ± 19.79a**
Inflammation ++++ ++ ++ ++++
  0.83 ± 0.41 4.5 ± 0.84a**** 2.5 ± 1.0b** 2.5 ± 1.2b** 4.4 ± 1.0
Necrosis + ++++ + + +++
  13.17 ± 4.8 64.83 ± 17.2a**** 23.17 ± 10.1b**** 22.33 ± 4.1b**** 43.5 ± 14.3b*
Vasodilation ++++ ++ +++ ++++
  1.8 ± 0.41 16.3 ± 4a*** 11.2 ± 4.7 12.5 ± 4.76 20.3 ± 7.2
Fibrosis +++ + ++++
  0.83 ± 0.41 6.83 ± 2.0a**** 1.3 ± 0.5b**** 1.8 ± 0.4b*** 7.3 ± 3.2
Hemorrhage +++ + ++ ++++
  1.5 ± 0.55 5.5 ± 0.55a**** 2.13 ± 0.95b*** 4.5 ± 2.1 9.167 ± 1.17b***
Steatosis + ++++
  1.3 ± 0.5 16.5 ± 5.1 3 ± 1.1 6.67 ± 1.6 48.5 ± 19.9b****
  1. Results are expressed as mean ± SD (n = 6)
  2. The histopathological changes were based on the average obtained from an observation of 10-microscopic fields with an area 625μm2 at 40x or 400x
  3. NC control, T Toxic, Mel15 Melittin15μg, Mel 30 Melittin30μg, NR Normal recovery
  4. Damages graded as follows: -, absent; +, trace (1–25%); ++, mild (25–50%); +++, moderate (50–75%); ++++, severe (75–100%). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001
  5. a: significant Vs NC group, b: significant Vs T group