Table 4 In situ evaluation of liver from rats that received melittin post isoniazid and rifampicin-induced hepatotoxicity

Amyloids

–

++++

–

–

+

1.33 ± 0.52

17.5 ± 6.47^a****

2.67 ± 1.21 ^b****

1.5 ± 0.55^b****

3.83 ± 1.72 ^b****

Congestion

+

++++

+

+

+++

1.33 ± 0.52

6.67 ± 1.36 ^a****

2.4 ± 1^b***

2.17 ± 0.98^b***

5.17 ± 2.56

Ballooned hepatocytes

–

++++

+

++

++

4 ± 2

86 ± 39.43^a****

30 ± 11.65^b**

49.4 ± 17.81

54.3 ± 19.79^a**

Inflammation

–

++++

++

++

++++

0.83 ± 0.41

4.5 ± 0.84^a****

2.5 ± 1.0^b**

2.5 ± 1.2^b**

4.4 ± 1.0

Necrosis

+

++++

+

+

+++

13.17 ± 4.8

64.83 ± 17.2^a****

23.17 ± 10.1^b****

22.33 ± 4.1^b****

43.5 ± 14.3^b*

Vasodilation

–

++++

++

+++

++++

1.8 ± 0.41

16.3 ± 4^a***

11.2 ± 4.7

12.5 ± 4.76

20.3 ± 7.2

Fibrosis

–

+++

–

+

++++

0.83 ± 0.41

6.83 ± 2.0^a****

1.3 ± 0.5^b****

1.8 ± 0.4^b***

7.3 ± 3.2

Hemorrhage

–

+++

+

++

++++

1.5 ± 0.55

5.5 ± 0.55^a****

2.13 ± 0.95^b***

4.5 ± 2.1

9.167 ± 1.17^b***

Steatosis

–

+

–

–

++++

1.3 ± 0.5

16.5 ± 5.1

3 ± 1.1

6.67 ± 1.6

48.5 ± 19.9^b****