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Table 3 Number of reports and crude reporting odds ratio of acute kidney injury associated with anti-infectives

From: Pharmacovigilance study of anti-infective-related acute kidney injury using the Japanese adverse drug event report database

Classification (ATC code) Total (n) Case (n) Crude RORa (95% CIb)
Total 534,688 21,727  
Antibacterials
 Tetracyclines (J01AA) 1763 75 1.05 (0.83–1.32)
 Amphenicols (J01BA) 49 0 c
 Penicillins with extended spectrum (J01CA) 3264 121 0.91 (0.76–1.09)
 Beta-lactamase sensitive penicillins (J01CE) 93 6 1.63 (0.71–3.72)
 Beta-lactamase resistant penicillins (J01CF) 0 0 c
 Beta-lactamase inhibitors (J01CG) 0 0 c
 Combinations of penicillins, incl. Beta-lactamase inhibitors (J01CR) 2121 292 3.81 (3.36–4.31)d
 First-generation cephalosporins (J01DB) 1484 46 0.75 (0.56–1.01)
 Second-generation cephalosporins (J01DC) 1902 101 1.33 (1.08–1.62)d
 Third-generation cephalosporins (J01DD) 7551 341 1.12 (1.002–1.25)d
 Fourth-generation cephalosporins (J01DE) 1318 128 2.55 (2.12–3.06)d
 Monobactams (J01DF) 21 4 5.56 (1.87–16.51)d
 Carbapenems (J01DH) 3551 313 2.30 (2.05–2.59)d
 Other cephalosporins and penems (J01DI) 132 9 1.73 (0.88–3.40)
 Trimethoprim and derivatives (J01EA) 0 0 c
 Intermediate-acting sulfonamides (J01EC) 36 7 5.70 (2.50–13.01)d
 Long-acting sulfonamides (J01ED) 4 0 c
 Combinations of sulfonamides and trimethoprim, incl. Derivatives (J01EE) 2738 261 2.51 (2.20–2.85)d
 Macrolides (J01FA) 5283 200 0.93 (0.81–1.07)
 Lincosamides (J01FF) 757 55 1.85 (1.41–2.44)d
 Streptogramins (J01FG) 2 0 c
 Streptomycins (J01GA) 153 9 1.48 (0.75–2.89)
 Other aminoglycosides (J01GB) 932 258 9.13 (7.91–10.55)d
 Fluoroquinolones (J01MA) 8571 494 1.45 (1.33–1.59)d
 Other quinolones (J01MB) 24 3 3.37 (1.01–11.31)d
 Combinations of antibacterials (J01RA) 638 11 0.41 (0.23–0.75)
 Glycopeptide antibacterials (J01XA) 2752 596 6.68 (6.10–7.32)d
 Polymyxins (J01XB) 137 107 84.62 (56.43–126.89)d
 Steroid antibacterials (J01XC) 2 0 c
 Imidazole derivatives (J01XD) 667 12 0.43 (0.24–0.77)
 Nitrofuran derivatives (J01XE) 0 0 c
 Other antibacterials (J01XX) 2119 107 1.26 (1.03–1.53)d
Antimycotics
 Antibiotics (J02AA) 1337 299 6.88 (6.05–7.83)d
 Imidazole derivatives (J02AB) 100 1 c
 Triazole derivatives (J02AC) 3130 315 2.67 (2.37–3.00)d
 Other antimycotics for systemic use (J02AX) 1148 161 3.87 (3.28–4.58)d
  1. a Reporting Odds Ratio, b Confidence Interval, c Number of cases < 2, d Lower limit of 95% CI > 1