Fig. 1

Chromatograms of DOX, DOXol and tropisetron (I.S.) in rat plasma. Blank plasma sample (A); a plasma sample spiked with DOX, DOXol, and tropisetron (I.S.), respectively (B); and a plasma sample obtained from a rat 10 min after intravenous administration of doxorubicin (C). 1.Tropisetron 2. Doxorubicinol 3. Doxorubicin