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Table 1 Pharmacokinetic parameters of DOX in control and ADI groups after single intravenous administration of DOX (7 mg/kg) (\( \overline{X} \) ± SD, n = 6)

From: Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma

Parameters Control ADI
t1/2α (h) 0.074 ± 0.005 0.089 ± 0.017**
t1/2β (h) 2.734 ± 1.385 2.638 ± 1.108
V1 (L/kg) 0.099 ± 0.026 0.028 ± 0.011**
CL (L/h/kg) 0.37 ± 0.15 0.099 ± 0.048*
AUC0-t (mg/L*h) 20.21 ± 11.22 76.50 ± 34.89**
K10 (1/h) 3.91 ± 1.67 3.68 ± 1.69
K12 (1/h) 5.26 ± 2.05 4.27 ± 0.73
K21 (1/h) 0.77 ± 0.49 0.65 ± 0.48
  1. Data are presented as mean ± SD (n = 6). *P < 0.05, **P < 0.01 versus control group
  2. t½α, half-life of distribution; t½β, half-life of elimination; V1, apparent volume of distribution in central compartment; CL, clearance; AUC0-t, area under plasma drug concentration-time curve; K10, elimination rate constant of drug from compartment 1; K12, rate constant for movement of drug from compartment 1 to compartment 2; K21, rate constant for movement of drug from compartment 2 to compartment 1