Table 1 Pharmacokinetic parameters of DOX in control and ADI groups after single intravenous administration of DOX (7 mg/kg) (\( \overline{X} \) ± SD, n = 6)

t_1/2α (h)

0.074 ± 0.005

0.089 ± 0.017**

t_1/2β (h)

2.734 ± 1.385

2.638 ± 1.108

V₁ (L/kg)

0.099 ± 0.026

0.028 ± 0.011**

CL (L/h/kg)

0.37 ± 0.15

0.099 ± 0.048*

AUC_0-t (mg/L*h)

20.21 ± 11.22

76.50 ± 34.89**

K₁₀ (1/h)

3.91 ± 1.67

3.68 ± 1.69

K₁₂ (1/h)

5.26 ± 2.05

4.27 ± 0.73

K₂₁ (1/h)

0.77 ± 0.49

0.65 ± 0.48