|
Parameters
|
Control
|
ADI
|
|---|
|
AUC0-t (mg/L*h)
|
5.62 ± 2.23
|
16.41 ± 2.91**
|
|
MRT0-t (h)
|
2.40 ± 0.32
|
5.33 ± 1.31**
|
|
t1/2z (h)
|
2.09 ± 0.98
|
4.99 ± 0.95**
|
|
Tmax (h)
|
0.33 ± 0.001
|
0.33 ± 0.001
|
|
CLz/F (L/h/kg)
|
1.33 ± 0.57
|
0.43 ± 0.08
|
|
Vz/F (L/kg)
|
4.43 ± 3.86
|
3.13 ± 0.98
|
|
Cmax (mg/L)
|
2.41 ± 1.04
|
8.34 ± 3.90**
|
- Data are presented as mean ± SD (n = 6). **P < 0.01 versus control group
- AUC0-t, area under plasma drug concentration-time curve; MRT0-t, mean residence time; t1/2z, half-life of elimination; Tmax, peak time; CLz, clearance; Vz, apparent volume of distribution; Cmax, maximum (peak) plasma drug concentration
