Table 2 Pharmacokinetic parameters of DOXol in control and ADI groups after single intravenous administration of DOX (7 mg/kg) (\( \overline{X} \) ± SD, n = 6)
Parameters | Control | ADI |
|---|---|---|
AUC0-t (mg/L*h) | 5.62 ± 2.23 | 16.41 ± 2.91** |
MRT0-t (h) | 2.40 ± 0.32 | 5.33 ± 1.31** |
t1/2z (h) | 2.09 ± 0.98 | 4.99 ± 0.95** |
Tmax (h) | 0.33 ± 0.001 | 0.33 ± 0.001 |
CLz/F (L/h/kg) | 1.33 ± 0.57 | 0.43 ± 0.08 |
Vz/F (L/kg) | 4.43 ± 3.86 | 3.13 ± 0.98 |
Cmax (mg/L) | 2.41 ± 1.04 | 8.34 ± 3.90** |