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Table 2 Pharmacokinetic parameters of DOXol in control and ADI groups after single intravenous administration of DOX (7 mg/kg) (\( \overline{X} \) ± SD, n = 6)

From: Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma

Parameters Control ADI
AUC0-t (mg/L*h) 5.62 ± 2.23 16.41 ± 2.91**
MRT0-t (h) 2.40 ± 0.32 5.33 ± 1.31**
t1/2z (h) 2.09 ± 0.98 4.99 ± 0.95**
Tmax (h) 0.33 ± 0.001 0.33 ± 0.001
CLz/F (L/h/kg) 1.33 ± 0.57 0.43 ± 0.08
Vz/F (L/kg) 4.43 ± 3.86 3.13 ± 0.98
Cmax (mg/L) 2.41 ± 1.04 8.34 ± 3.90**
  1. Data are presented as mean ± SD (n = 6). **P < 0.01 versus control group
  2. AUC0-t, area under plasma drug concentration-time curve; MRT0-t, mean residence time; t1/2z, half-life of elimination; Tmax, peak time; CLz, clearance; Vz, apparent volume of distribution; Cmax, maximum (peak) plasma drug concentration