Fig. 1

Study setup and impact of increasing doses of 3HB-Na on mortality and severity of illness. A, Study design. White box: healthy mice, Gray boxes: Septic mice. Full lines: increasing dose because of no increased lethality, dashed lines: decreasing dose because of increased lethality. B, Cumulative severity of illness of critically ill mice. Data are shown as medians. Number of animals equals total number of animals reported in panel c. glc: glucose, PN: parenteral nutrition, mg/d: mg per day. C, Cumulative survival of the study. Number (n) of animals is reported as n = survivors/total