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Fig. 7 | BMC Pharmacology and Toxicology

Fig. 7

From: Identification of the toxic threshold of 3-hydroxybutyrate-sodium supplementation in septic mice

Fig. 7

Impact of increasing doses of 3HB-Na on muscle force and wasting in septic mice. A, Ex vivo EDL muscle force measurements presented as specific force (peak tetanic tension per unit muscle mass). White, healthy (n = 13); dashes, PN + glc (n = 12); PN + 3HB-Na: black, 150 mg/d (n = 13); light gray, 180 mg/d (n = 12); gray, 225/300 mg/d (n = 8). B, EDL muscle dry weight. White, healthy (n = 13); dashes, PN + glc (n = 15); PN + 3HB-Na: black, 150 mg/d (n = 16); light gray, 180 mg/d (n = 12); gray, 225/300 mg/d (n = 8). A, B Data are shown as median and interquartile range. glc: glucose, PN: parenteral nutrition, mg/d: mg per day

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