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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment

Fig. 5

The effects of pretreatment of MitoQ or SKQ1 on Dox-induced cell viability reduction. The representative pictures of cells (100 X) after pretreatment are shown in A (scale bar: 50 μm). The effects of MitoQ and SKQ1 pretreatment on Dox-induced cell damage are illustrated in B. Higher doses of MitoQ or SKQ1 significantly improved cell viability when given as pretreatment. Moreover, MitoQ exerted significantly higher protection than SKQ1. *p < 0.05; **p < 0.01 vs Dox; ##p < 0.01 vs SKQ1

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