Fig. 8

Effects of co-treatment or pretreatment of SKQ1 or MitoQ on Dox-induced increase in intracellular ROS levels. Co-treatment (A) and pretreatment (B) of SKQ1 and MitoQ significantly attenuated Dox-induced increase in intracellular ROS levels when compared to Dox alone. Pretreatment (C-D) showed better reduction in intracellular ROS levels than co-treatment only at a higher dose (5 μM). Moreover, MitoQ exerted a significantly higher reduction in intracellular ROS levels than SKQ1. **p < 0.01 vs Dox; #p < 0.05, ##p < 0.01 vs MitoQ or SKQ1, respectively