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Table 3 Block1: Substrate Classification Models for Cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A4. Block 2: Inhibition models for cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A4 (qualitative es-timation), as well as a specific inhibition of the CYP 3A4-mediated metabolism of midazolam and testosterone. We labeled Y if a given chemical structure is a substrate for P450 isozymes and (N) if it is not a substrate for P450 isozymes. ADMET Risk and ADMET Code for metabolic liability are CYP_risk and CYP_code, respectively. Metabolic risk greater than 2 is highlighted with red, while the acceptable values are highlighted with green. Cyp risk rules and codes are described in the risk section

From: Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19