|
Michaelis – Menten
|
1
|
3
|
Determination of enzyme saturation
|
Not perfect
|
|
Non – linear kinetic
|
17
|
17
|
Determination of rate – limiting and non – rate limiting enzymes in mixed order kinetics
|
Derived from Michaelis – Menten equation
|
|
Cellular metabolic rate
|
5
|
3
|
Determines minimum and maximum level of metabolism in cells
|
Obeys Eadie-Hofstee plot
|
|
Kinetics beyond Michaelis – Menten
|
11
|
6
|
Determination of drugs metabolized by allosteric enzymes
|
Benzodiazepines as the examples
|
|
Non – linear mixed kinetic
|
15
|
10
|
Determination of in vivo kinetics
|
Simple method of determining drug disposition
|
|
Narrow therapeutic window
|
2
|
0
|
Determination of safe doses
|
It is good for renal impaired patient
|
|
Combined Michaelis – Menten
|
3
|
0
|
Identification of liver enzyme inducers/inhibitors
|
In vitro/In vivo integrated for balanced kinetics/dynamics
|
