Skip to main content

Table 2 Statistics of in vivo kinetic equations

From: Application of modified Michaelis – Menten equations for determination of enzyme inducing and inhibiting drugs

Equation Types

Number of Equations

Modified Equations

Applications

Remarks

Michaelis – Menten

1

3

Determination of enzyme saturation

Not perfect

Non – linear kinetic

17

17

Determination of rate – limiting and non – rate limiting enzymes in mixed order kinetics

Derived from Michaelis – Menten equation

Cellular metabolic rate

5

3

Determines minimum and maximum level of metabolism in cells

Obeys Eadie-Hofstee plot

Kinetics beyond Michaelis – Menten

11

6

Determination of drugs metabolized by allosteric enzymes

Benzodiazepines as the examples

Non – linear mixed kinetic

15

10

Determination of in vivo kinetics

Simple method of determining drug disposition

Narrow therapeutic window

2

0

Determination of safe doses

It is good for renal impaired patient

Combined Michaelis – Menten

3

0

Identification of liver enzyme inducers/inhibitors

In vitro/In vivo integrated for balanced kinetics/dynamics