Table 3 Metabolic parameters of some drugs generated from Vmax and Km using modified Michaelis-Menten equations
Drug | Binding Site | Metabolites | Dose (mg) | Vmax | Km | Cs | R | CMR | Vo | Clint | % saturation | S/Km | Status | pH | References |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Theophylline (mg) | Adenosine receptor/RNA | 1, 3 – DMU | 300 | 34.2 | 14.2 | 1.08 | 0.18 | 14.85 | 2.60 | 2.41 | 7.07 | 0.08 | Inducer | Weak base | [25] |
1 – MU | 300 | 13.1 | 9.3 | 1.12 | 0.17 | 5.69 | 1.58 | 1.41 | 10.74 | 0.12 | Inducer | Week base | [24] | ||
3 - MX | 300 | 4.9 | 2.0 | 2.0 | 2.45 | 2.13 | 4.90 | 2.45 | 50.00 | 1.00 | Inducer | Weak base | [25] | ||
Mibefradil (mg) | Globulin | Dealkylated | 100 | 6.79 | 70.2 | 1.02 | 0.003 | 2.95 | 0.10 | 0.097 | 1.43 | 0.01 | Inhibitor | Base | [57] |
Voriconazole (ng) | Albumin/globulin | Hydroxylated | 400 | 114 | 1.15 | 7.67 | 661.2 | 49.51 | 160.33 | 99.13 | 86.96 | 6.67 | Inducer | Acidic | [6] |
Metronidazole (μm) | Plasma protein | 2-hydroxy | 300 | 0.366 | 0.911 | 1.00 | 0.00 | 0.16 | 4.02 | 4.02 | 52.32 | 1.10 | Inhibitor | Acidic | [23] |
metronidazole | 300 | 0.527 | 0.235 | 0.31 | −2.10 | 0.23 | 0.14 | 2.24 | 56.88 | 1.32 | Inhibitor | Acidic | [1] | ||
Isoniazid (mg) | Protein | Isonicotinic acid | 250 | 30.87 | 1.669 | 2.50 | 27.75 | 13.41 | 46.25 | 18.50 | 59.97 | 1.50 | Inhibitor | Base | [35] |
Puromicin(mg) | Ribosome | 5′-monophosphate | 100 | 193.9 | 0.0435 | 0.00 | 0.00 | 84.21 | 0.00 | 0.875 | 0.00 | 0.00 | Inhibitor | Acidic-basic | [15] |
Phenytoin (mg) | Na + receptor | Phenylhydantoin | 300 | 8.25 | 9.43 | 0.049 | 0.00 | 3.58 | 0.00 | 0.043 | 0.52 | 0.01 | Inducer | Base | [7] |
R – Thiopental(mg) | GABAA | – | 120 | 0.86 | 20.0 | 1.03 | −0.002 | 0.37 | 0.04 | 0.042 | 4.90 | 0.05 | Inducer | Base | [10] |
Phenytoin (mg) | Na + receptor | Hydroxyphenytoin | 300 | 28.0 | 91.0 | 1.01 | 0.23 | 12.16 | 0.31 | 0.308 | 1.10 | 0.01 | Inducer | Base | [37] |
S – Thiopental (mg) | GABAA | – | 300 | 1.01 | 24.0 | 1.04 | 0.002 | 0.44 | 0.04 | 0.042 | 4.15 | 0.04 | Inducer | Base | [33] |
Thymidine(mg) | Nucleoside | Baminoisobutyric acid | – | 2.45 | 45.5 | 1.00 | 0.00 | 1.06 | 0.053 | 0.053 | 2.15 | 0.02 | Inducer | Acidic | [11] |
Thymine(mg) | DNA | – | – | 2.55 | 82.5 | 0.98 | 0.00 | 1.11 | 0.03 | 0.030 | 1.17 | 0.01 | Inducer | Base | [12] |
Fluorouracil(mg) | Albumin | Dihydrofluorouracil | – | 2.16 | 39.8 | 1.02 | 0.006 | 0.94 | 0.06 | 0.054 | 2.50 | 0.03 | Inducer | Base | [13] |
Tylosin(mg) | Ribosome | Relomycin | 110 | 0.018 | 0.37 | 0.58 | −0.021 | 0.01 | 0.028 | 0.049 | 61.05 | 1.57 | Inducer | Acid-basic | [1] |