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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis

Fig. 2

Gene expression levels of proinflammatory cytokines and TGF-β in response to treatment with PPAR agonists. Hepatic mRNA levels were determined using quantitative real-time PCR and normalized to β-actin mRNA expression. Values are expressed as the mean ± S.D. of fold changes relative to the NC. Between-group, comparisons were tested by ANOVA followed by Tukey Kramer multiple comparisons test. TNF- α, tumor necrosis factor-alpha; IL-6, interleukin 6; MCP-1, monocyte chemoattractant protein 1; TGF-β, transforming growth factor-beta. *p < 0.05; **p < 0.01; ***p < 0.001; and ns (nonsignificant) vs. HF. # p < 0.001 vs. NC

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