Fig. 3

Histopathological evaluation of the NASH model following treatment with PPAR agonists. Upper, representative images of hematoxylin-eosin and Masson Trichrome stained liver tissue sections with 100X magnification in different groups at the end of treatments. C: congestion; I: inflammation; S: steatosis; F: fibrosis. Lower, mean ± S.D. of scores measured for steatosis, congestion, and inflammation after H&E staining and for fibrosis, deposition of collagen was evaluated using the Masson’s trichrome staining (n = 7). *p < 0.05, **p < 0.01, ***p < 0.001 vs. NC; † p < 0.05, †† p < 0.01, ††† p < 0.001 vs. HF