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Table 2 hematologic and biochemical parameters in different experimental groups

From: The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication

Variables Control Tramadol Tramadol + single Quercetin Tramadol + chronic Quercetin Tramadol + single Quercetin + Naloxone
WBC10*3/μL 3.12 ± 0.9 4.02 ± 1.3 5.8 ± 1.4 * 5.2 ± 1.4 4.8 ± 1.3
RBC 10*6/μL 8.5 ± 0.9 8.98 ± 0.4 9.2 ± 0.3 8.34 ± 0.5 9.23 ± 0.4
HGB (g/dL) 14.9 [13.1, 15.25] 14.7 [14.25,15.75] † 15.3[14.85, 16.2] † 13.45 [13.05,14.05] 15.5 [14.97, 15.95] †
HCT (%) 45.5[40.85,46.9] 46.1 [43.65, 48.15] 47.1[45.1, 49.65] 41.15 [40.55,44.17] 47.15 [46.5, 48.7]
PLT (10*3/μL) 516.7 ± 21.7 † 478.2 ± 46.51 † 516.8 ± 69.5 † 727.16 ± 58.04 412.5 ± 38.31 †
MCV (μm*3) 51.8[51.2,52.7] 50.7 [50.6, 51.95] 51.4[50, 52.85] 50.05 [49.65, 51.9] 50.7 [50.47, 50.7]
MCHC (g/dL) 32.5[32,32.7] 32.7 [32, 32.95] 32.9[32.3, 33.05] 32.35 [31.82, 32.7] 32.7 [32, 33.17]
MCH (pg) 16.84 ± 0.2 16.62 ± 0.3 16.82 ± 0.4 16.28 ± 0.4 16.77 ± 0.4
LYM (%) 64.2 ± 7.7 66.2 ± 9.4 52.1 ± 14.6 52 ± 9.1 61.5 ± 9.7
MON (%) 0.62 ± 0.4 0.66 ± 0.4 1.44 ± 0.9 1.76 ± 0.5 1.47 ± 0.8
NEU (%) 32 ± 7.9 31 ± 10.5 44.2 ± 15.4 43.7 ± 8.1 34.5 ± 10.6
EOS (%) 2.4 ± 1.3 1.96 ± 2.3 0.9 ± 0.1 0.8 ± 0.6 1.57 ± 0.2
BAS (%) 1.7 [0.07, 2.1] 2.4 [0, 3.3] 3.2 [0.1, 5.5] 2.9 [0.4, 4.7] 2.9 [0.3, 3.5]
NEU/LYM ratio 0.51 ± 0.1 0.49 ± 0.2 0.94 ± 0.4 0.87 ± 0.2 0.59 ± 0.2
Glucose (mg/dl) 136.6 ± 18.08 154.3 ± 25.1 137.1 ± 18.3 123.3 ± 18.8 131.8 ± 12.4
Cr (mg/dl) 0.35 ± 0.04 0.36 ± 0.05 0.34 ± 0.08 0.32 ± 0.05 0.44 ± 0.21
AST (IU/L) 110.6 [91.6, 146.3] 177 [135.6, 203.5] 148.3 [138.2, 216.9] 157.05 [125.3, 182.6] 180.5 [145.6, 435.7]
ALT (IU/L) 59.4 ± 11 52.3 ± 11.4 39.1 ± 5.7 34.5 ± 16.3 79.2 ± 50.8†
AST/ALT ratio 1.9 [1.8, 2.1] 3.3 [2.6, 4.2] * 4.2 [3.1, 5.7] * 4.1 [3.1, 13.5] * 3.1 [2.7, 4.3] *
  1. WBC, White Blood count; RBC, Red Blood count; HGB, hemoglobin; HCT, hematocrit; PLT, platelet; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; LYM, Lymphocytes; MON, Monocytes; NEU, Neutrophils; EOS, Eosinophils; BAS, Basophils; Cr, creatinine; AST, aspartate aminotransferase; ALT, alanine aminotransferase
  2. Statistical comparison between groups was made using one-way ANOVA followed by Bonferroniposthoc or Kruskal Wallis test and Dunn-Bonferroni post hoc
  3. * p < 0.05 significant as compared to the control group
  4. p < 0.05 significant as compared to Tramadol + chronic Quercetin group