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Table 2 hematologic and biochemical parameters in different experimental groups

From: The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication

Variables

Control

Tramadol

Tramadol + single Quercetin

Tramadol + chronic Quercetin

Tramadol + single Quercetin + Naloxone

WBC10*3/μL

3.12 ± 0.9

4.02 ± 1.3

5.8 ± 1.4 *

5.2 ± 1.4

4.8 ± 1.3

RBC 10*6/μL

8.5 ± 0.9

8.98 ± 0.4

9.2 ± 0.3

8.34 ± 0.5

9.23 ± 0.4

HGB (g/dL)

14.9 [13.1, 15.25]

14.7 [14.25,15.75] †

15.3[14.85, 16.2] †

13.45 [13.05,14.05]

15.5 [14.97, 15.95] †

HCT (%)

45.5[40.85,46.9]

46.1 [43.65, 48.15]

47.1[45.1, 49.65]

41.15 [40.55,44.17]

47.15 [46.5, 48.7]

PLT (10*3/μL)

516.7 ± 21.7 †

478.2 ± 46.51 †

516.8 ± 69.5 †

727.16 ± 58.04

412.5 ± 38.31 †

MCV (μm*3)

51.8[51.2,52.7]

50.7 [50.6, 51.95]

51.4[50, 52.85]

50.05 [49.65, 51.9]

50.7 [50.47, 50.7]

MCHC (g/dL)

32.5[32,32.7]

32.7 [32, 32.95]

32.9[32.3, 33.05]

32.35 [31.82, 32.7]

32.7 [32, 33.17]

MCH (pg)

16.84 ± 0.2

16.62 ± 0.3

16.82 ± 0.4

16.28 ± 0.4

16.77 ± 0.4

LYM (%)

64.2 ± 7.7

66.2 ± 9.4

52.1 ± 14.6

52 ± 9.1

61.5 ± 9.7

MON (%)

0.62 ± 0.4

0.66 ± 0.4

1.44 ± 0.9

1.76 ± 0.5

1.47 ± 0.8

NEU (%)

32 ± 7.9

31 ± 10.5

44.2 ± 15.4

43.7 ± 8.1

34.5 ± 10.6

EOS (%)

2.4 ± 1.3

1.96 ± 2.3

0.9 ± 0.1

0.8 ± 0.6

1.57 ± 0.2

BAS (%)

1.7 [0.07, 2.1]

2.4 [0, 3.3]

3.2 [0.1, 5.5]

2.9 [0.4, 4.7]

2.9 [0.3, 3.5]

NEU/LYM ratio

0.51 ± 0.1

0.49 ± 0.2

0.94 ± 0.4

0.87 ± 0.2

0.59 ± 0.2

Glucose (mg/dl)

136.6 ± 18.08

154.3 ± 25.1

137.1 ± 18.3

123.3 ± 18.8

131.8 ± 12.4

Cr (mg/dl)

0.35 ± 0.04

0.36 ± 0.05

0.34 ± 0.08

0.32 ± 0.05

0.44 ± 0.21

AST (IU/L)

110.6 [91.6, 146.3]

177 [135.6, 203.5]

148.3 [138.2, 216.9]

157.05 [125.3, 182.6]

180.5 [145.6, 435.7]

ALT (IU/L)

59.4 ± 11

52.3 ± 11.4

39.1 ± 5.7

34.5 ± 16.3

79.2 ± 50.8†

AST/ALT ratio

1.9 [1.8, 2.1]

3.3 [2.6, 4.2] *

4.2 [3.1, 5.7] *

4.1 [3.1, 13.5] *

3.1 [2.7, 4.3] *

  1. WBC, White Blood count; RBC, Red Blood count; HGB, hemoglobin; HCT, hematocrit; PLT, platelet; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; LYM, Lymphocytes; MON, Monocytes; NEU, Neutrophils; EOS, Eosinophils; BAS, Basophils; Cr, creatinine; AST, aspartate aminotransferase; ALT, alanine aminotransferase
  2. Statistical comparison between groups was made using one-way ANOVA followed by Bonferroniposthoc or Kruskal Wallis test and Dunn-Bonferroni post hoc
  3. * p < 0.05 significant as compared to the control group
  4. † p < 0.05 significant as compared to Tramadol + chronic Quercetin group