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Table 3 Inflammatory and oxidative stress parameters of serum in different experimental groups

From: The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication

Groups Variable Control Tramadol Tramadol + single Quercetin Tramadol + chronic quercetin Tramadol + single Quercetin + Naloxone
NOx (μmol/l) 24.9 [19, 54.8] 51.4 [26.2, 73.9] 27.9 [11.16, 81.9] 22.1 [12.5, 27.6] 33.39 [12.18, 108.6]
SOD (U/ml) 439.5 ± 50.3 494.6 ± 99.1 527.9 ± 78.2 574.4 ± 76.5 441.5 ± 86.9
MDA (μmol/l) 2.15 ± 0.2 2.32 ± 0.3 2.39 ± 0.3 2.21 ± 0.4 2.5 ± 0.7
IL-6 (ng/L) 8.6 ± 3.4 11.4 ± 4.5 12.87 ± 4.4 13.01 ± 4 10.08 ± 1.7
Tnf-a (pg/mL) 10.32 ± 1.1 13.86 ± 4.3 13.7 ± 2.8 15.2 ± 1.3* 14.6 ± 0.8*
  1. Statistical comparison between groups was made using one-way ANOVA followed by Bonferroniposthoc or Kruskal Wallis test and Dunn-Bonferroni post hoc
  2. NOx: Nitric Oxide, SOD: Superoxide dismutase, MDA: Malondialdehyde, IL-6: interleukin-6, Tnf-a: Tumour Necrosis Factor-alpha
  3. * p < 0.05 significant as compared to the control group