Skip to main content

Table 2 Activity of Selected Compounds against Leishmania aethiopica promastigotes

From: In vitro growth inhibitory activity of Medicines for Malaria Venture pathogen box compounds against Leishmania aethiopica

Plate–well location MMV ID IC50 (95% CI) Cytotoxicity, CC50 (SI), μM Mode of action Previous activity report
Sheep RBC THP-1
B-F5 MMV637229 0.483 (0.340–0.740) > 25 (ND) > 25 (ND) Antihistamine T. cruzi, L. donovani [19, 24]
C-E8 MMV690102 0.158 (0.086–0.213) > 25 (ND) 36 (478) * DHFR inhibitors L.donovani, L.mexicana [24, 25]
C-F3 MMV688179 0.356 (0.180–0.440) > 25 (ND) > 25 (ND) DNA interfere with DNA multiplication T. brucei and L. donovani [24]
D-B5 MMV024829 0.356 (0.174–0.352) > 25 (ND) > 25 (ND)
D-B7 MMV022029 0.305 (0.241–0.364) > 25 (ND) > 25 (ND) T. brucei [24]
D-D11 MMV024406 0.024 (0.016–0.031) > 25 (ND) > 25 (ND) C. albicans [26]
D-E4 MMV085071 0.283 (0.110–0.471) > 25 (ND) > 25 (ND) DV disruption, mitochondrial degradation & DNA fragmentation P. falciparum [27]
D-F11 MMV687812 0.390 (0.285–0.502) > 25 (ND) > 25 (ND) DV-disrupting/ DNA degradation P. falciparum [27]
D-G6 MMV663250 0.326 (0.190–0.530) > 25 (ND) > 25 (ND)
D-H3 MMV022478 0.448 (0.138–0.580) > 25 (ND) > 25 (ND) NADPH oxidase inhibitors via inhibition of protein kinase C [28] L. donovani, T. gondi [18, 19, 24]
E-G11 MMV688415 0.145 (0.102–0.180) > 25 (ND) > 25 (ND) T. cruzi [24]
Amphotericin B 0. 106 (0.06–0.140)     
Pentamidine 1.31 (0.728–1.92)     
  1. Description: 95% CI 95% confidence interval, IC50 Median inhibitory concentration, DV digestive vacuole, SI selectivity index, ND not determined, *extrapolated result. The IC50 value indicated was the average of two independent experiments conducted in triplicate