|
B-F5
|
MMV637229
|
0.483 (0.340–0.740)
|
> 25 (ND)
|
> 25 (ND)
|
Antihistamine
|
T. cruzi, L. donovani [19, 24]
|
|
C-E8
|
MMV690102
|
0.158 (0.086–0.213)
|
> 25 (ND)
|
36 (478) *
|
DHFR inhibitors
|
L.donovani, L.mexicana [24, 25]
|
|
C-F3
|
MMV688179
|
0.356 (0.180–0.440)
|
> 25 (ND)
|
> 25 (ND)
|
DNA interfere with DNA multiplication
|
T. brucei and L. donovani [24]
|
|
D-B5
|
MMV024829
|
0.356 (0.174–0.352)
|
> 25 (ND)
|
> 25 (ND)
|
–
|
–
|
|
D-B7
|
MMV022029
|
0.305 (0.241–0.364)
|
> 25 (ND)
|
> 25 (ND)
|
–
|
T. brucei [24]
|
|
D-D11
|
MMV024406
|
0.024 (0.016–0.031)
|
> 25 (ND)
|
> 25 (ND)
|
–
|
C. albicans [26]
|
|
D-E4
|
MMV085071
|
0.283 (0.110–0.471)
|
> 25 (ND)
|
> 25 (ND)
|
DV disruption, mitochondrial degradation & DNA fragmentation
|
P. falciparum [27]
|
|
D-F11
|
MMV687812
|
0.390 (0.285–0.502)
|
> 25 (ND)
|
> 25 (ND)
|
DV-disrupting/ DNA degradation
|
P. falciparum [27]
|
|
D-G6
|
MMV663250
|
0.326 (0.190–0.530)
|
> 25 (ND)
|
> 25 (ND)
|
–
|
–
|
|
D-H3
|
MMV022478
|
0.448 (0.138–0.580)
|
> 25 (ND)
|
> 25 (ND)
|
NADPH oxidase inhibitors via inhibition of protein kinase C [28]
|
L. donovani, T. gondi [18, 19, 24]
|
|
E-G11
|
MMV688415
|
0.145 (0.102–0.180)
|
> 25 (ND)
|
> 25 (ND)
|
–
|
T. cruzi [24]
|
|
Amphotericin B
|
0. 106 (0.06–0.140)
| | | | |
|
Pentamidine
|
1.31 (0.728–1.92)
| | | | |
