Plate–well location | MMV ID | IC50 (95% CI) | Cytotoxicity, CC50 (SI), μM | Mode of action | Previous activity report | |
---|---|---|---|---|---|---|
Sheep RBC | THP-1 | |||||
B-F5 | MMV637229 | 0.483 (0.340–0.740) | > 25 (ND) | > 25 (ND) | Antihistamine | |
C-E8 | MMV690102 | 0.158 (0.086–0.213) | > 25 (ND) | 36 (478) * | DHFR inhibitors | |
C-F3 | MMV688179 | 0.356 (0.180–0.440) | > 25 (ND) | > 25 (ND) | DNA interfere with DNA multiplication | T. brucei and L. donovani [24] |
D-B5 | MMV024829 | 0.356 (0.174–0.352) | > 25 (ND) | > 25 (ND) | – | – |
D-B7 | MMV022029 | 0.305 (0.241–0.364) | > 25 (ND) | > 25 (ND) | – | T. brucei [24] |
D-D11 | MMV024406 | 0.024 (0.016–0.031) | > 25 (ND) | > 25 (ND) | – | C. albicans [26] |
D-E4 | MMV085071 | 0.283 (0.110–0.471) | > 25 (ND) | > 25 (ND) | DV disruption, mitochondrial degradation & DNA fragmentation | P. falciparum [27] |
D-F11 | MMV687812 | 0.390 (0.285–0.502) | > 25 (ND) | > 25 (ND) | DV-disrupting/ DNA degradation | P. falciparum [27] |
D-G6 | MMV663250 | 0.326 (0.190–0.530) | > 25 (ND) | > 25 (ND) | – | – |
D-H3 | MMV022478 | 0.448 (0.138–0.580) | > 25 (ND) | > 25 (ND) | NADPH oxidase inhibitors via inhibition of protein kinase C [28] | |
E-G11 | MMV688415 | 0.145 (0.102–0.180) | > 25 (ND) | > 25 (ND) | – | T. cruzi [24] |
Amphotericin B | 0. 106 (0.06–0.140) | |||||
Pentamidine | 1.31 (0.728–1.92) |