Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro

Table 3 Potencies of NSAIDs as inhibitors of rat liver oleamide hydrolase activity

NSAID	pIC50 (M)	NSAID	pIC50 (M)
Sulindac	3.65 ± 0.08	Ibuprofen	3.01 ± 0.06
Carprofen	3.58 ± 0.09	Valdecoxib	3.00 ± 0.15
Meclofenamic acid	3.57 ± 0.06	Ketorolac	2.91 ± 0.07
Sulindac sulphone	3.35 ± 0.03	Diclofenac	2.90 ± 0.07
Indomethacin	3.28 ± 0.03	Dipyrone	2.77 ± 0.07
Diflunisal	3.15 ± 0.04

Data are mean ± SEM (Standard Error of the Mean) of four separate preparations (n=4) conducted in triplicate

ISSN: 2050-6511