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Table 3 Potencies of NSAIDs as inhibitors of rat liver oleamide hydrolase activity

From: Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro

NSAID pIC50 (M) NSAID pIC50 (M)
Sulindac 3.65 ± 0.08 Ibuprofen 3.01 ± 0.06
Carprofen 3.58 ± 0.09 Valdecoxib 3.00 ± 0.15
Meclofenamic acid 3.57 ± 0.06 Ketorolac 2.91 ± 0.07
Sulindac sulphone 3.35 ± 0.03 Diclofenac 2.90 ± 0.07
Indomethacin 3.28 ± 0.03 Dipyrone 2.77 ± 0.07
Diflunisal 3.15 ± 0.04   
  1. Data are mean ± SEM (Standard Error of the Mean) of four separate preparations (n=4) conducted in triplicate