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Table 1 Comparison between UDP and traditional acute toxicity test methods

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Method Mice Time (day) Precision
UDP [31] 4 ~ 15 20 ~ 42 95% CI was wide, imprecise
Traditional acute toxicity methods
 Bliss method [5] ~ 80 14 95% CI was narrow, precise
 mKM [32] ~ 80 14 95% CI was narrow, precise