From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method
Method
Mice
Time (day)
Precision
UDP [31]
4 ~ 15
20 ~ 42
95% CI was wide, imprecise
Traditional acute toxicity methods
Bliss method [5]
~ 80
14
95% CI was narrow, precise
mKM [32]