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Table 1 Comparison between UDP and traditional acute toxicity test methods

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Method

Mice

Time (day)

Precision

UDP [31]

4 ~ 15

20 ~ 42

95% CI was wide, imprecise

Traditional acute toxicity methods

 Bliss method [5]

~ 80

14

95% CI was narrow, precise

 mKM [32]

~ 80

14

95% CI was narrow, precise