Table 10 Lethality and signs of toxicity of mice administrated with sinomenine hydrochloride by mKM
Group | n | Dosage (mg/kg) | Morality (p) | p2 | Pathology |
|---|---|---|---|---|---|
1 | 10 | 300 | 0 | 0 | No visible alterations were found in organs and tissues |
2 | 10 | 365 | 0.3 | 0.09 | Liver was enlarged and congested |
3 | 10 | 446 | 0.4 | 0.16 | Liver was enlarged and congested |
4 | 10 | 544 | 0.7 | 0.49 | Liver and kidney were enlarged and congested |
5 | 10 | 663 | 0.9 | 0.81 | Liver and kidney were significantly enlarged and congested |