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Table 10 Lethality and signs of toxicity of mice administrated with sinomenine hydrochloride by mKM

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Group n Dosage (mg/kg) Morality (p) p2 Pathology
1 10 300 0 0 No visible alterations were found in organs and tissues
2 10 365 0.3 0.09 Liver was enlarged and congested
3 10 446 0.4 0.16 Liver was enlarged and congested
4 10 544 0.7 0.49 Liver and kidney were enlarged and congested
5 10 663 0.9 0.81 Liver and kidney were significantly enlarged and congested