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Table 11 Effect of different doses of sinomenine hydrochloride on organ indexes in ICR mice by mKM

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Dosage (mg/kg) Heart (%) Liver (%) Spleen (%) Lung (%) Kidney (%)
0 0.466 ± 0.002 4.800 ± 0.373 0.387 ± 0.079 0.588 ± 0.057 1.282 ± 0.140
300 0.494 ± 0.091 4.948 ± 0.500 0.404 ± 0.085 0.571 ± 0.109 1.217 ± 0.184
365 0.454 ± 0.036 4.925 ± 0.298 0.393 ± 0.063 0.586 ± 0.092 1.101 ± 0.104
446 0.403 ± 0.012 4.382 ± 0.442 0.335 ± 0.082 0.519 ± 0.110 1.210 ± 0.035
544 0.421 ± 0.037 3.931 ± 0.240 0.327 ± 0.078 0.543 ± 0.022 1.109 ± 0.110*
663 0.345 ± 0.035** 4.327 ± 0.248 0.305 ± 0.021 0.554 ± 0.054 0.973 ± 0.063**
  1. Note: *P < 0.05 vs Normal, **P < 0.01 vs Normal