Skip to main content

Table 11 Effect of different doses of sinomenine hydrochloride on organ indexes in ICR mice by mKM

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Dosage (mg/kg)

Heart (%)

Liver (%)

Spleen (%)

Lung (%)

Kidney (%)

0

0.466 ± 0.002

4.800 ± 0.373

0.387 ± 0.079

0.588 ± 0.057

1.282 ± 0.140

300

0.494 ± 0.091

4.948 ± 0.500

0.404 ± 0.085

0.571 ± 0.109

1.217 ± 0.184

365

0.454 ± 0.036

4.925 ± 0.298

0.393 ± 0.063

0.586 ± 0.092

1.101 ± 0.104

446

0.403 ± 0.012

4.382 ± 0.442

0.335 ± 0.082

0.519 ± 0.110

1.210 ± 0.035

544

0.421 ± 0.037

3.931 ± 0.240

0.327 ± 0.078

0.543 ± 0.022

1.109 ± 0.110*

663

0.345 ± 0.035**

4.327 ± 0.248

0.305 ± 0.021

0.554 ± 0.054

0.973 ± 0.063**

  1. Note: *P < 0.05 vs Normal, **P < 0.01 vs Normal