Table 12 Lethality and signs of toxicity of mice administered with berberine hydrochloride by mKM
Group | n | Dosage (mg/kg) | Morality (p) | p2 | Pathology |
|---|---|---|---|---|---|
1 | 10 | 703 | 0.2 | 0.04 | No visible alterations were found in other organs and tissues |
2 | 10 | 1406 | 0.3 | 0.09 | No visible alterations were found in other organs and tissues |
3 | 10 | 2812 | 0.4 | 0.16 | No visible alterations were found in other organs and tissues |
4 | 10 | 5628 | 0.7 | 0.49 | Lung were enlarged |
5 | 10 | 11,250 | 0.9 | 0.81 | Liver and lung were enlarged, and spleen was reduced |