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Table 12 Lethality and signs of toxicity of mice administered with berberine hydrochloride by mKM

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Group n Dosage (mg/kg) Morality (p) p2 Pathology
1 10 703 0.2 0.04 No visible alterations were found in other organs and tissues
2 10 1406 0.3 0.09 No visible alterations were found in other organs and tissues
3 10 2812 0.4 0.16 No visible alterations were found in other organs and tissues
4 10 5628 0.7 0.49 Lung were enlarged
5 10 11,250 0.9 0.81 Liver and lung were enlarged, and spleen was reduced