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Table 14 Classification Criteria for Acute Toxicity [46]

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Exposure route

Category I

Highest toxicity

Category II

Toxicity

Category III

Moderately toxicity

Category IV

Mildly toxicity

Category V

Low acute toxicity

Oral (mg/kg)

<5

5 ~ 50

51 ~ 300

301 ~ 2000

2001 ~ 5000