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Table 15 Comparison of acute toxicity results between iUDP and mKM in three alkaloids

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Method Compound Category Animals Compound (g) Expense (MOP) Duration (Day)
iUDP Nicotine II 7 0.0082 1330 21
Sinomenine hydrochloride IV 7 0.114 1330 21
Berberine hydrochloride V 9 1.9 1900 24
mKM Nicotine II 74 0.0673 14,060 14
Sinomenine hydrochloride IV 80 1.24 15,200 14
Berberine hydrochloride V 86 12.7 16,340 14