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Table 3 Effect of nicotine on organ indexes in ICR mice by iUDP

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Dosage (mg/kg) Heart (%) Liver (%) Spleen (%) Lung (%) Kidney (%)
0 0.466 ± 0.002 4.800 ± 0.373 0.387 ± 0.079 0.588 ± 0.057 1.282 ± 0.140
12.6 0.491 4.665 0.370 0.609 1.248
20 0.485 4.250 0.381 0.643 1.185
32 0.474 ± 0.018 4.548 ± 0.505 0.366 ± 0.084 0.653 ± 0.056** 1.170 ± 0.058
50 0.581 ± 0.051** 5.123 ± 0.155 0.385 ± 0.063 0.702 ± 0.015** 1.107 ± 0.007
  1. Note: *P < 0.05 vs Normal, **P < 0.01 vs Normal