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Table 3 Effect of nicotine on organ indexes in ICR mice by iUDP

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Dosage (mg/kg)

Heart (%)

Liver (%)

Spleen (%)

Lung (%)

Kidney (%)

0

0.466 ± 0.002

4.800 ± 0.373

0.387 ± 0.079

0.588 ± 0.057

1.282 ± 0.140

12.6

0.491

4.665

0.370

0.609

1.248

20

0.485

4.250

0.381

0.643

1.185

32

0.474 ± 0.018

4.548 ± 0.505

0.366 ± 0.084

0.653 ± 0.056**

1.170 ± 0.058

50

0.581 ± 0.051**

5.123 ± 0.155

0.385 ± 0.063

0.702 ± 0.015**

1.107 ± 0.007

  1. Note: *P < 0.05 vs Normal, **P < 0.01 vs Normal