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Table 4 Lethality and signs of toxicity of mice administered with sinomenine hydrochloride by iUDP

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Seq. Dosage (mg/kg) Δm (g) Short-term outcome Symptoms Pathology
1 175 1.1 O Mild, shortness of breath, frightened, recovered after 2 h No visible alterations were found in organs
2 280 1.4 O Shortness of breath, frightened, recovered after 5 h No visible alterations were found in organs
3 440 1.8 O Tremor, breathlessness, and recovered after 2 h Liver was enlarged
4 700 1.3 X Severe tremor, weakness, dead after 30 min Liver was enlarged
5 440 1.5 O Mild tremor, weakness, and recovered after 2 h Liver and kidney were enlarged
6 700 0.9 X Severe tremor, weakness, dead after 1 h Liver was enlarged
7 440 0.9 X Breathlessness, tremor, and dead after 4 h Liver and kidney were enlarged
Stop criteria met: 5 reversals in 6 tests
  1. Note: The sequence of outcomes: O for alive and X for dead