Table 4 Lethality and signs of toxicity of mice administered with sinomenine hydrochloride by iUDP

1

175

1.1

O

Mild, shortness of breath, frightened, recovered after 2 h

No visible alterations were found in organs

2

280

1.4

O

Shortness of breath, frightened, recovered after 5 h

No visible alterations were found in organs

3

440

1.8

O

Tremor, breathlessness, and recovered after 2 h

Liver was enlarged

4

700

1.3

X

Severe tremor, weakness, dead after 30 min

Liver was enlarged

5

440

1.5

O

Mild tremor, weakness, and recovered after 2 h

Liver and kidney were enlarged

6

700

0.9

X

Severe tremor, weakness, dead after 1 h

Liver was enlarged

7

440

0.9

X

Breathlessness, tremor, and dead after 4 h

Liver and kidney were enlarged