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Table 5 Effect of sinomenine hydrochloride on organ indexes in ICR mice by iUDP

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Dosage (mg/kg)

Heart (%)

Liver (%)

Spleen (%)

Lung (%)

Kidney (%)

0

0.466 ± 0.002

4.800 ± 0.373

0.387 ± 0.079

0.588 ± 0.057

1.282 ± 0.140

175

0.550

4.660

0.312

0.623

1.120

280

0.450

4.258

0.467

0.578

1.295

440

0.403 ± 0.012

4.382 ± 0.442

0.345 ± 0.082

0.519 ± 0.110

1.110 ± 0.035*

700

0.315 ± 0.065**

4.452 ± 0.486

0.293 ± 0.033**

0.566 ± 0.065

1.005 ± 0.085**

  1. Note: *P < 0.05 vs Normal, **P < 0.01 vs Normal