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Table 5 Effect of sinomenine hydrochloride on organ indexes in ICR mice by iUDP

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Dosage (mg/kg) Heart (%) Liver (%) Spleen (%) Lung (%) Kidney (%)
0 0.466 ± 0.002 4.800 ± 0.373 0.387 ± 0.079 0.588 ± 0.057 1.282 ± 0.140
175 0.550 4.660 0.312 0.623 1.120
280 0.450 4.258 0.467 0.578 1.295
440 0.403 ± 0.012 4.382 ± 0.442 0.345 ± 0.082 0.519 ± 0.110 1.110 ± 0.035*
700 0.315 ± 0.065** 4.452 ± 0.486 0.293 ± 0.033** 0.566 ± 0.065 1.005 ± 0.085**
  1. Note: *P < 0.05 vs Normal, **P < 0.01 vs Normal