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Table 8 Lethality and signs of toxicity of mice administrated with nicotine by mKM

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Group n Dosage (mg/kg) Morality (p) p2 Pathology
1 10 16 0.2 0.04 No visible alterations were found in other organs and tissues.
2 10 20 0.3 0.09 Liver was enlarged and congested
3 10 25 0.7 0.49 Liver was enlarged and congested
4 10 31.25 0.8 0.64 Liver and kidney were enlarged and congested
5 10 39.1 0.9 0.81 Liver and kidney were significantly enlarged and congested
  1. Note: The sequence of outcomes: O for alive and X for dead