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Table 8 Lethality and signs of toxicity of mice administrated with nicotine by mKM

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Group

n

Dosage (mg/kg)

Morality (p)

p2

Pathology

1

10

16

0.2

0.04

No visible alterations were found in other organs and tissues.

2

10

20

0.3

0.09

Liver was enlarged and congested

3

10

25

0.7

0.49

Liver was enlarged and congested

4

10

31.25

0.8

0.64

Liver and kidney were enlarged and congested

5

10

39.1

0.9

0.81

Liver and kidney were significantly enlarged and congested

  1. Note: The sequence of outcomes: O for alive and X for dead