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Table 9 Effect of different doses of nicotine on organ indexes in ICR mice by mKM

From: Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method

Dosage (mg/kg) Heart (%) Liver (%) Spleen (%) Lung (%) Kidney (%)
0 0.466 ± 0.002 4.800 ± 0.373 0.387 ± 0.079 0.588 ± 0.057 1.282 ± 0.140
16 0.467 ± 0.023 4.667 ± 0.317 0.412 ± 0.066 0.603 ± 0.046 1.177 ± 0.075
20 0.482 ± 0.061 4.772 ± 0.476 0.468 ± 0.068 0.603 ± 0.081 1.220 ± 0.064
25 0.431 ± 0.002 4.825 ± 0.034 0.578 ± 0.154 0.665 ± 0.038* 1.211 ± 0.021
31.25 0.437 ± 0.009 4.272 ± 0.363 0.423 ± 0.022 0.692 ± 0.058** 1.187 ± 0.052
39.10 0.490 ± 0.041 4.891 ± 0.105 0.391 ± 0.055 0.700 ± 0.020** 1.137 ± 0.09
  1. Note: *P < 0.05 vs Normal, **P < 0.01 vs Normal