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Table 3 Absolute and relative organ weights from female rats treated orally with Py-mulin for 28 days

From: Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate

Parameters

0 mg/kg b.w.

50 mg/kg b.w.

100 mg/kg b.w.

300 mg/kg b.w.

Absolute organ weight (g)

 Heart

0.75 ± 0.10

0.70 ± 0.10

0.82 ± 0.06

0.81 ± 0.07

 Liver

6.89 ± 0.83

7.29 ± 0.90

7.65 ± 1.01

7.88 ± 0.53*

 Spleen

0.44 ± 0.08

0.48 ± 0.05

0.42 ± 0.08

0.49 ± 0.07

 Lungs

1.04 ± 0.11

1.12 ± 0.13

1.08 ± 0.12

1.05 ± 0.14

 Kidneys

1.35 ± 0.14

1.39 ± 0.17

1.41 ± 0.15

1.43 ± 0.17

 Thymus

0.35 ± 0.05

0.37 ± 0.06

0.42 ± 0.06

0.41 ± 0.07

 Ovaries

0.09 ± 0.02

0.12 ± 0.03

0.11 ± 0.03

0.11 ± 0.04

Organ-to-body weight ratio (%)

 Heart

0.39 ± 0.04

0.37 ± 0.04

0.42 ± 0.03

0.41 ± 0.03

 Liver

3.61 ± 0.30

3.88 ± 0.33

3.95 ± 0.40

3.97 ± 0.10*

 Spleen

0.23 ± 0.03

0.26 ± 0.03

0.22 ± 0.03

0.25 ± 0.03

 Lungs

0. 55 ± 0.05

0.59 ± 0.04

0.56 ± 0.04

0.52 ± 0.06

 Kidneys

0.71 ± 0.05

0.74 ± 0.06

0.73 ± 0.07

0.72 ± 0.05

 Thymus

0.18 ± 0.02

0.20 ± 0.03

0.22 ± 0.02*

0.21 ± 0.03

 Ovaries

0.05 ± 0.01

0.06 ± 0.02

0.06 ± 0.02

0.06 ± 0.02

  1. Values are mean ± SD for 10 rats in each group
  2. *Statistically significant difference compared to control (p < 0.05)