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Table 3 Absolute and relative organ weights from female rats treated orally with Py-mulin for 28 days

From: Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate

Parameters 0 mg/kg b.w. 50 mg/kg b.w. 100 mg/kg b.w. 300 mg/kg b.w.
Absolute organ weight (g)
 Heart 0.75 ± 0.10 0.70 ± 0.10 0.82 ± 0.06 0.81 ± 0.07
 Liver 6.89 ± 0.83 7.29 ± 0.90 7.65 ± 1.01 7.88 ± 0.53*
 Spleen 0.44 ± 0.08 0.48 ± 0.05 0.42 ± 0.08 0.49 ± 0.07
 Lungs 1.04 ± 0.11 1.12 ± 0.13 1.08 ± 0.12 1.05 ± 0.14
 Kidneys 1.35 ± 0.14 1.39 ± 0.17 1.41 ± 0.15 1.43 ± 0.17
 Thymus 0.35 ± 0.05 0.37 ± 0.06 0.42 ± 0.06 0.41 ± 0.07
 Ovaries 0.09 ± 0.02 0.12 ± 0.03 0.11 ± 0.03 0.11 ± 0.04
Organ-to-body weight ratio (%)
 Heart 0.39 ± 0.04 0.37 ± 0.04 0.42 ± 0.03 0.41 ± 0.03
 Liver 3.61 ± 0.30 3.88 ± 0.33 3.95 ± 0.40 3.97 ± 0.10*
 Spleen 0.23 ± 0.03 0.26 ± 0.03 0.22 ± 0.03 0.25 ± 0.03
 Lungs 0. 55 ± 0.05 0.59 ± 0.04 0.56 ± 0.04 0.52 ± 0.06
 Kidneys 0.71 ± 0.05 0.74 ± 0.06 0.73 ± 0.07 0.72 ± 0.05
 Thymus 0.18 ± 0.02 0.20 ± 0.03 0.22 ± 0.02* 0.21 ± 0.03
 Ovaries 0.05 ± 0.01 0.06 ± 0.02 0.06 ± 0.02 0.06 ± 0.02
  1. Values are mean ± SD for 10 rats in each group
  2. *Statistically significant difference compared to control (p < 0.05)